Evidence map›Paper›PMID 25061513›Full record

ArticleMicrobiome2014

Effect of chemotherapy on the microbiota and metabolome of human milk, a case report.

Camilla Urbaniak, Amy McMillan, Michelle Angelini, Gregory B Gloor, Mark Sumarah, Jeremy P Burton, Gregor Reid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
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  12. Observational
  13. Frontiers in nutrition · 2021
    Article
  14. Breast Milk: A Meal Worth Having.Frontiers in nutrition · 2021
    Review
  15. Review
  16. Review
  17. Preterm neonatal immunology at the intestinal interface.Cellular and molecular life sciences : CMLS · 2020
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camilla UrbaniakLawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Microbiology & Immunology, Western University, London, ON N6A 5C1, Canada.
Amy McMillanLawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Microbiology & Immunology, Western University, London, ON N6A 5C1, Canada.
Michelle AngeliniPerinatal and Women's Health, London Health Sciences Centre, London, ON N6A 4L6, Canada.
Gregory B GloorDepartment of Biochemistry, Western University, London, ON N6A 5C1, Canada.
Mark SumarahDepartment of Chemistry, Western University, London, ON N6A 5C1, Canada ; Agriculture and Agri-Food Canada, London, ON N5V 4T3, Canada.
Jeremy P BurtonLawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Microbiology & Immunology, Western University, London, ON N6A 5C1, Canada.
Gregor ReidLawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada ; Department of Microbiology & Immunology, Western University, London, ON N6A 5C1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman milk is an important source of bacteria for the developing infant and has been shown to influence the bacterial composition of the neonatal gut, which in turn can affect disease risk later in life. Human milk is also an important source of nutrients, influencing bacterial composition but also directly affecting the host. While recent studies have emphasized the adverse effects of antibiotic therapy on the infant microbiota, the effects of maternal chemotherapy have not been previously studied. Here we report the effects of drug administration on the microbiota and metabolome of human milk.

methodsMature milk was collected every two weeks over a four month period from a lactating woman undergoing chemotherapy for Hodgkin's lymphoma. Mature milk was also collected from healthy lactating women for comparison. Microbial profiles were analyzed by 16S sequencing and the metabolome by gas chromatography-mass spectrometry.

findingsChemotherapy caused a significant deviation from a healthy microbial and metabolomic profile, with depletion of genera Bifidobacterium, Eubacterium, Staphylococcus and Cloacibacterium in favor of Acinetobacter, Xanthomonadaceae and Stenotrophomonas. The metabolites docosahexaenoic acid and inositol known for their beneficial effects were also decreased.

conclusionWith milk contents being critical for shaping infant immunity and development, consideration needs to be given to the impact of drugs administered to the mother and the long-term potential consequences for the health of the infant.

Indexed as

16S rRNA gene sequencingHuman milk microbiomeMetabolome

Identifiers

PMID25061513
PMCPMC4109383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.