ArticleNeuropsychiatric disease and treatment2014
The predictive value of somatic and cognitive depressive symptoms for cytokine changes in patients with major depression.
Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls.Brain, behavior, and immunity · 2020Pooled it
- Differential associations of passively sensed behaviors with in-vivo depression symptoms.Journal of psychopathology and clinical science · 2025Article
- Inflammatory Cytokines, but Not Dietary Patterns, Are Related to Somatic Symptoms of Depression in a Sample of Women.Frontiers in psychiatry · 2022Article
- The longitudinal connection between depressive symptoms and inflammation: Mediation by sleep quality.PloS one · 2022Article
- Inflammation and the dimensions of depression: A review.Frontiers in neuroendocrinology · 2020Review
- Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway.Journal of inflammation research · 2020Article
- Cerebellar Fastigial Nucleus Stimulation in a Chronic Unpredictable Mild Stress Rat Model Reduces Post-Stroke Depression by Suppressing Brain Inflammation via the microRNA-29c/TNFRSF1A Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Hepatitis C Pretreatment Profile and Gender Differences: Cognition and Disease Severity Effects.Frontiers in psychology · 2019Article
- Precuneus abnormalities in middle-aged to older adults with depressive symptoms: An analysis of BDI-II symptom dimensions.Psychiatry research. Neuroimaging · 2017Article
- Cytokines and depression in cancer patients and caregivers.Neuropsychiatric disease and treatment · 2017Article
- Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics.Frontiers in psychiatry · 2017Article
- The role of interleukin genes in the course of depression.Open medicine (Warsaw, Poland) · 2016Article
- Beta-adrenergic receptor mediated inflammation control by monocytes is associated with blood pressure and risk factors for cardiovascular disease.Brain, behavior, and immunity · 2015Article
- Depression Dimensions: Integrating Clinical Signs and Symptoms from the Perspectives of Clinicians and Patients.PloS one · 2015Article
- Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults.Journal of psychiatry & neuroscience : JPNArticle
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextElevated concentrations of proinflammatory cytokines have been hypothesized as an important factor in the pathophysiology of depression. Depression itself is considered to be a heterogeneous disorder. Current findings suggest that "cognitive" and "somatic" symptom dimensions are related to immune function in different ways. So far, little research has been done on the longitudinal aspects of inflammation in patients with major depression, especially with respect to different symptom dimensions of depression. Therefore, we investigated which aspects of depression may predict changes in tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 over 4 weeks.
methodsForty-one patients with major depression diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), and 45 healthy controls were enrolled. Serum measurements of TNF-alpha and IL-6 were conducted at baseline and 4 weeks later. Psychometric measures included the assessment of cognitive-affective depressive symptoms and somatic symptoms during the last 7 days as well as somatic symptoms during the last 2 years.
resultsPatients with depression showed increased levels of TNF-alpha (P<0.05) compared to healthy controls. Hierarchical regression analyses indicated that neither depressive nor somatic symptoms predict changes in proinflammatory cytokines in the whole sample of depressed patients. Moderation analyses and subsequent sex-stratified regression analyses indicated that higher somatoform symptoms during the last 2 years significantly predict an increase in TNF-alpha in women with major depression (P<0.05) but not in men. Exploratory analyses indicated that the stability of TNF-alpha and IL-6 (as indicated by intraclass correlation coefficients) over 4 weeks was high for TNF-alpha but lower for IL-6.
conclusionThe present study demonstrated that a history of somatoform symptoms may be important for predicting future changes in TNF-alpha in women with major depression.
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