Evidence map›Paper›PMID 25061300›Full record

ArticleNeuropsychiatric disease and treatment2014

Towards Horizon 2020: challenges and advances for clinical mental health research - outcome of an expert survey.

Christina M van der Feltz-Cornelis, Jim van Os, Susanne Knappe, Gunter Schumann, Eduard Vieta, Hans-Ulrich Wittchen, Shôn W Lewis, Iman Elfeddali, Kristian Wahlbeck, Donald Linszen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
43.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Christina M van der Feltz-CornelisTrimbos Instituut, Utrecht, the Netherlands ; Tilburg University, Tranzo Department, Tilburg, the Netherlands ; GGz Breburg, Tilburg, the Netherlands.
Jim van OsDepartment of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, Euron, Maastricht University Medical Center, Maastricht, the Netherlands ; Institute of Psychiatry, King's College London, London, UK.
Susanne KnappeInstitute of Clinical Psychology and Psychotherapy and Center for Epidemiology and Longitudinal Studies, Technische Universität Dresden, Dresden, Germany.
Gunter SchumannInstitute of Psychiatry, King's College London, London, UK.
Eduard VietaInstitute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Hans-Ulrich WittchenInstitute of Clinical Psychology and Psychotherapy and Center for Epidemiology and Longitudinal Studies, Technische Universität Dresden, Dresden, Germany.
Shôn W LewisInstitute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
Iman ElfeddaliTilburg University, Tranzo Department, Tilburg, the Netherlands ; Department of Health Promotion/School of Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands.
Kristian WahlbeckThe Nordic School of Public Health, Gothenburg, Sweden ; National Institute for Health and Welfare, Helsinki, Finland.
Donald LinszenDepartment of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, Euron, Maastricht University Medical Center, Maastricht, the Netherlands.
Carla Obradors-TarragóCentro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain ; Research and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Spain.
Josep Maria HaroCentro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain ; Research and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Spain ; Universitat de Barcelona, Barcelona, Spain.
TU Dresden · DEKing's College London · GBMaastricht University · NLUniversitat de Barcelona · ESUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe size and increasing burden of disease due to mental disorders in Europe poses substantial challenges to its population and to the health policy of the European Union. This warrants a specific research agenda concerning clinical mental health research as one of the cornerstones of sustainable mental health research and health policy in Europe. The aim of this research was to identify the top priorities needed to address the main challenges in clinical research for mental disorders.

methodsThe research was conducted as an expert survey and expert panel discussion during a scientific workshop.

resultsEighty-nine experts in clinical research and representing most European countries participated in this survey. Identified top priorities were the need for new intervention studies, understanding the diagnostic and therapeutic implications of mechanisms of disease, and research in the field of somatic-psychiatric comorbidity. The "subjectivity gap" between basic neuroscience research and clinical reality for patients with mental disorders is considered the main challenge in psychiatric research, suggesting that a shift in research paradigms is required.

conclusionInnovations in clinical mental health research should bridge the gap between mechanisms underlying novel therapeutic interventions and the patient experience of mental disorder and, if present, somatic comorbidity. Clinical mental health research is relatively underfunded and should receive specific attention in Horizon 2020 funding programs.

Indexed as

challengeclinical researchEuropeexpert surveyHorizon 2020mental healthrandomized clinical trialsresearch agenda

Identifiers

PMID25061300
PMCPMC4085314
OpenAlexW2111674744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.