ArticleInternational journal of nanomedicine2014
Anticancer nanodelivery system with controlled release property based on protocatechuate-zinc layered hydroxide nanohybrid.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Green Synthesized Montmorillonite/Carrageenan/FeInternational journal of molecular sciences · 2020Article
- Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system.International journal of nanomedicine · 2017Article
- Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy.Nanoscale research letters · 2016Article
- Unique antitumor property of the Mg-Ca-Sr alloys with addition of Zn.Scientific reports · 2016Article
- Impact of size, secondary structure, and counterions on the binding of small ribonucleic acids to layered double hydroxide nanoparticles.Biointerphases · 2015Article
- Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes.Beilstein journal of nanotechnology · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe characterize a novel nanocomposite that acts as an efficient anticancer agent.
methodsThis nanocomposite consists of zinc layered hydroxide intercalated with protocatechuate (an anionic form of protocatechuic acid), that has been synthesized using a direct method with zinc oxide and protocatechuic acid as precursors.
resultsThe resulting protocatechuic acid nanocomposite (PAN) showed a basal spacing of 12.7 Å, indicating that protocatechuate was intercalated in a monolayer arrangement, with an angle of 54° from the Z-axis between the interlayers of the zinc layered hydroxide, and an estimated drug loading of about 35.7%. PAN exhibited the properties of a mesoporous type material, with greatly enhanced thermal stability of protocatechuate as compared to its free counterpart. The presence of protocatechuate in the interlayers of the zinc layered hydroxide was further supported by Fourier transform infrared spectroscopy. Protocatechuate was released from PAN in a slow and sustained manner. This mechanism of release was well represented by a pseudo-second order kinetics model. PAN has shown increased cytotoxicity compared to the free form of protocatechuic acid in all cancer cell lines tested. Tumor growth suppression was extensive, particularly in HepG2 and HT29 cell lines.
conclusionPAN is suitable for use as a controlled release formulation, and our in vitro evidence indicates that PAN is an effective anticancer agent. PAN may have potential as a chemotherapeutic drug for human cancer.
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