ArticleInternational journal of chronic obstructive pulmonary disease2014
Extent and prevalence of cognitive dysfunction in chronic obstructive pulmonary disease, chronic non-obstructive bronchitis, and in asymptomatic smokers, compared to normal reference values.
Article in International journal of chronic obstructive pulmonary disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The relationship between cognitive function and arterial partial pressure O2 in patients with COPD: A meta-analysis.Medicine · 2018Pooled it
- Brain structural changes in COPD patients with cognitive impairment.Journal of neurology · 2026Review
- A Narrative Review of the Correlation Between Comorbidity and Acute Exacerbation of COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Review
- Observational
- Associations of Upper-Extremity Exercise Capacity and Grip Strength With Cognitive Domains in Patients With COPD.Respiratory care · 2024Article
- Association between weight-adjusted-waist index and cognitive decline in US elderly participants.Frontiers in nutrition · 2024Article
- Smoking related attention alteration in chronic obstructive pulmonary disease-smoking comorbidity.BMC pulmonary medicine · 2022Article
- Mid-Term Effects of Pulmonary Rehabilitation on Cognitive Function in People with Severe Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2020Observational
- Chronic Cough and Phlegm in Subjects Undergoing Comprehensive Health Examination in Japan - Survey of Chronic Obstructive Pulmonary Disease Patients Epidemiology in Japan (SCOPE-J).International journal of chronic obstructive pulmonary disease · 2020Article
- Memory, attention and fluency deficits in COPD may be a specific form of cognitive impairment.ERJ open research · 2019Article
- Clinical effects of cognitive impairment in patients with chronic obstructive pulmonary disease.Chronic respiratory disease · 2018Article
- The outcome and the influencing factors of the age of onset in post-mortem of chronic bronchitis patients: a retrospective study.International journal of chronic obstructive pulmonary disease · 2018Article
- The effects of depression, anxiety and sleep disturbances on cognitive impairment in patients with chronic obstructive pulmonary disease.Cognitive neurodynamics · 2017Article
- Recognition, diagnosis, and treatment of cognitive and psychiatric disorders in patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Review
- Guiding Principles for the Use of Nebulized Long-Acting Beta2-Agonists in Patients with COPD: An Expert Panel Consensus.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2016Article
- Effects of common chronic medical conditions on psychometric tests used to diagnose minimal hepatic encephalopathy.Metabolic brain disease · 2016Article
- The economic impact of educational training assessed by the Handling Questionnaire with three inhalation devices in asthma and Chronic Obstructive Pulmonary Disease patients.ClinicoEconomics and outcomes research : CEOR · 2016Article
- Cognitive dysfunction in severe chronic obstructive pulmonary disease (COPD) with or without Long-Term Oxygen Therapy (LTOT).Multidisciplinary respiratory medicine · 2015Article
- Balance impairment and systemic inflammation in chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2015Article
- Prevalence of different comorbidities in COPD patients by gender and GOLD stage.Multidisciplinary respiratory medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic obstructive pulmonary disease (COPD) can affect cognition. The effects of other less severe chronic airway disorders on cognition remain to be clarified. This study aimed to measure and compare cognitive deterioration in subjects with COPD, subjects with chronic non-obstructive bronchitis (CNOB), and asymptomatic smokers (AS), and to relate the corresponding prevalence to several demographic and clinical variables and to normal reference values.
methodsFour hundred and two subjects (COPD n=229, CNOB n=127, and AS n=46) of comparable age were included in the study. Cognitive impairment was assessed using the Mini Mental Status test, the Clock Drawing test, and the Trail Making test A and B.
resultsThe extent and prevalence of cognitive deterioration was greater in COPD subjects, followed by CNOB subjects and AS (P<0.001). The Medical Research Council and COPD Assessment test scores, forced expiratory volume in the first second predicted, and arterial partial pressure of O2 and of CO2 were related to the extent and the prevalence of cognitive deterioration. COPD subjects, CNOB subjects, and AS aged 40-69 years showed the greatest cognitive impairment (P<0.01 compared to normal values). This was particularly clear in COPD subjects.
conclusionCognitive impairment may start at the early stages of chronic airway damage and progress with a worsening of the respiratory condition. Indeed, the greatest cognitive deterioration was seen in COPD subjects. Cognition impairment may contribute to explaining the insufficient adherence to therapeutic plans and strategies, and the increasing social costs in respiratory subjects.
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