SynthesisClinical interventions in aging2014
Estrogen receptor α gene polymorphisms and risk of Alzheimer's disease: evidence from a meta-analysis.
Synthesis in Clinical interventions in aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia.Acta neurologica Belgica · 2021Pooled it
- Association Between ESR1 PvuII, XbaI, and P325P Polymorphisms and Breast Cancer Susceptibility: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- The Association between cognitive impairment and anthropometric indices among the elderly: birjand longitudinal aging study.Journal of diabetes and metabolic disorders · 2024Article
- Association between body mass index and cognitive impairment in Chinese older adults.Frontiers in public health · 2023Article
- Role of uric acid as a biomarker of cognitive function in schizophrenia during maintenance period.Frontiers in psychiatry · 2023Article
- Estrogen receptors and the aging brain.Essays in biochemistry · 2021Review
- Association between body mass index, its change and cognitive impairment among Chinese older adults: a community-based, 9-year prospective cohort study.European journal of epidemiology · 2021Article
- Estrogen receptor α: a critical role in successful female cognitive aging.Climacteric : the journal of the International Menopause Society · 2021Article
- Estrogen receptor α polymorphism is associated with dementia in a Brazilian cohort.Oncotarget · 2020Article
- Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females.Brain sciences · 2018Article
- Knowledge-Based Neuroendocrine Immunomodulation (NIM) Molecular Network Construction and Its Application.Molecules (Basel, Switzerland) · 2018Article
- Serum levels of GPER-1 in euthymic bipolar patients.Neuropsychiatric disease and treatment · 2018Article
- Article
- Does genetic testing for ERα gene polymorphisms provide new possibilities of treatment for cognitive function disorders in postmenopausal women?Archives of medical science : AMS · 2017Article
- Cognitive Functions, Concentration of Endogenous Estradiol, Estrogen Receptor α (ERα) Polymorphism in Postmenopausal Women.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman estrogen receptor α (ESR1), a member of the nuclear receptor superfamily of ligand-activated transcription factors, is one of the key mediators of hormonal response in estrogen-sensitive tissues. Accumulating evidence has demonstrated that two of the most widely studied single-nucleotide polymorphisms in ESR1 - PvuII (T/C, rs223493) and Xbal (A/G, rs9340799) - are possibly associated with Alzheimer's disease (AD). However, individual study results are still controversial. MATERIALS AND
methodsWe searched PubMed, Embase, Web of Science, Science Direct, SpringerLink, and the Chinese National Knowledge Infrastructure databases for eligible studies assessing the association of ESR1 polymorphisms and AD risk (last search performed in November 2013). Thereafter, a meta-analysis of 13,192 subjects from 18 individual studies was conducted to evaluate the association between ESR1 polymorphisms and susceptibility to AD.
resultsThe results indicated that a significant association was found between the ESR1 PvuII polymorphism and AD risk in Caucasian populations (CC + CT versus TT, odds ratio [OR] 1.14, 95% confidence interval [CI] 1.02-1.28, P=0.03; CT versus TT, OR 1.16, 95% CI 1.02-1.31, P=0.02), whereas no evidence of association was found in Asian populations. Nevertheless, we did not find any significant association between the ESR1 XbaI polymorphism and AD risk for any model in Caucasian and Asian populations (all P>0.05).
conclusionBased on this meta-analysis, we conclude that the ESR1 PvuII polymorphism might be a risk factor in AD development in Caucasian populations, not in Asian populations. Further confirmation is needed from better-designed and larger studies.
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