Evidence map›Paper›PMID 25061252›Full record

ArticleSleep2014

Examining the mechanism of action of a new device using oral pressure therapy for the treatment of obstructive sleep apnea.

Richard J Schwab, C Kim, Lawrence Siegel, B T Keenan, Jed Black, Mehran Farid-Moayer, Jonathan Podmore, Matt Vaska

Abstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Recent advances in managing obstructive sleep apnea.World journal of clinical cases · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richard J SchwabDivision of Sleep Medicine, Pulmonary Allergy and Critical Care Division and Center for Sleep & Circadian Neurobiology, Philadelphia PA.
C KimDivision of Sleep Medicine, Pulmonary Allergy and Critical Care Division and Center for Sleep & Circadian Neurobiology, Philadelphia PA.
Lawrence SiegelStanford University School of Medicine, Stanford, CA ; ApniCure, Redwood City CA.
B T KeenanDivision of Sleep Medicine, Pulmonary Allergy and Critical Care Division and Center for Sleep & Circadian Neurobiology, Philadelphia PA.
Jed BlackStanford University School of Medicine, Stanford, CA.
Mehran Farid-MoayerPeninsula Sleep Center, Burlingame, CA.
Jonathan PodmoreApniCure, Redwood City CA.
Matt VaskaApniCure, Redwood City CA.

Funding

Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7M
Obesity & OSA: Understanding the Importance of Tongue Fat and Metabolic FunctionR01HL089447 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHWAB, RICHARD J. · 2008 to 2011
$2.4M
NHLBI NIH HHS P01HL094307NHLBI NIH HHS R01HL089447
6 · The paper itself

Abstract

STUDY

objectivesThe objective of this study was to explore the mechanism of action of the oral pressure therapy (OPT) device, a new treatment for sleep apnea.

designCase series.

settingAcademic medical center. PATIENTS: Fifteen subjects with sleep apnea who had been successfully treated (responders) with the OPT device and 4 subjects who were not successfully treated (non-responders) with the OPT device.

interventionsAll subjects underwent a MRI (without the device, with the device in place without vacuum and with the device in place with vacuum) to examine the biomechanical changes associated with the OPT device. MEASUREMENTS AND

resultsOral pressure therapy significantly (P = 0.002) increased the size of the retropalatal airway in both the lateral and anterior-posterior dimensions by moving the soft palate anteriorly and superiorly and the anterior-superior segment of the tongue forward, toward the teeth. The percentage and absolute increase in the cross-sectional area of the retropalatal region, the superior movement of the soft palate, and the anterior displacement of the tongue were significantly greater in the responders than in the non-responders. In responders, there were significant increases in the mean (P = 0.002), maximum (P = 0.0002), and minimum (P = 0.04) cross-sectional areas of the retropalatal region with the OPT device. However, in the retroglossal region, airway caliber decreased with the OPT device.

conclusionsIn those who responded to oral pressure therapy, it increased airway caliber in the retropalatal region by moving the soft palate anteriorly and superiorly and the anterior-superior segment of the tongue forward. CITATION: Schwab RJ, Kim C, Siegel L, Keenan BT, Black J, Farid-Moayer M, Podmore J, Vaska M. Examining the mechanism of action of a new device using oral pressure therapy for the treatment of obstructive sleep apnea.

Indexed as

MovementPressureAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPalate, SoftPolysomnographyRespiratory SystemSleep Apnea, ObstructiveTongueYoung AdultMRIoral pressure therapysleep apneaupper airway imaging

Identifiers

PMID25061252
PMCPMC4098809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.