Thermally-Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates.

Ralph J Knipp, Rosendo Estrada, Palaniappan Sethu, Michael H Nantz

Abstract read

In one paragraph

Article in Tetrahedron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Time- and spatially resolved LNA delivery via thermally controlled SPION technology.Molecular therapy. Nucleic acids · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ralph J KnippDepartment of Chemistry, University of Louisville, Louisville, KY 40292, USA.

Rosendo EstradaDepartment of Bioengineering, University of Louisville, Louisville, KY 40292, USA.

Palaniappan SethuDepartment of Bioengineering, University of Louisville, Louisville, KY 40292, USA.

Michael H NantzDepartment of Chemistry, University of Louisville, Louisville, KY 40292, USA.

Funding

Integrated Chemoselective and Informatic Platform for Large-Scale MetabolomicsR01ES022191 · NIEHS · UNIVERSITY OF LOUISVILLE · PI FAN, TERESA WHEI-MEI, HIGASHI, RICHARD M · 2012 to 2016

$3.4M

NIEHS NIH HHS R01 ES022191

6 · The paper itself

Abstract

The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 °C was observed only for the 7-membered ring progenitors. Applicability of the approach was illustrated by δ-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe.

Indexed as

drug deliverylactamoxazolidinonepoly(dimethylsiloxane) microchannel

Identifiers

PMID25061237

DOI10.1016/j.tet.2014.03.092

PMCPMC4104717

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.