Evidence map›Paper›PMID 25061091›Full record

ArticleThe oncologist2014

Pre-exercise participation cardiovascular screening in a heterogeneous cohort of adult cancer patients.

Aarti A Kenjale, Whitney E Hornsby, Theresa Crowgey, Samantha Thomas, James E Herndon, Michel G Khouri, Amy R Lane, Caroline E Bishop, Neil D Eves, Jeffrey Peppercorn and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The oncologist, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Exercise Training in Cancer Survivors.Current oncology reports · 2016
    Review
  9. Precision Oncology Framework for Investigation of Exercise As Treatment for Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015
    Article
  10. A framework for prescription in exercise-oncology research.Journal of cachexia, sarcopenia and muscle · 2015
    Article
  11. Article
  12. In reply.The oncologist · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Aarti A KenjaleDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Whitney E HornsbyDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Theresa CrowgeyDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Samantha ThomasDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
James E HerndonDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Michel G KhouriDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Amy R LaneDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Caroline E BishopDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Neil D EvesDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jeffrey PeppercornDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Pamela S DouglasDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Lee W JonesDuke University Medical Center, Durham, North Carolina, USA; School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada; Memorial Sloan Kettering Cancer Center, New York, New York, USA jonesl3@mskcc.org.

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
NCI NIH HHS P30 CA014236
6 · The paper itself

Abstract

backgroundThe purpose of this study was to investigate the extent of pre-exercise participation ("preparticipation") health screening in a heterogeneous cohort of adult cancer patients.

methodsPatients (n = 413) with histologically confirmed solid or hematologic malignancy were categorized into preparticipation health screening risk stratification based on American College Sports Medicine (ACSM) recommendations. Risk of an exercise-related event was evaluated during a symptom-limited cardiopulmonary exercise test (CPET) with 12-lead electrocardiography (ECG).

resultsParticipant risk was categorized as low risk (n = 59, 14%), moderate risk (n = 217, 53%), and high risk (n = 137, 33%). Mean peak oxygen consumption was 21.7 ± 6.7 mL/kg(-1) per minute(-1) or 19.5 ± 21.7% below age- and sex-predicted sedentary values. No major serious adverse events or fatal events were observed during CPET procedures. A total of 31 positive ECG tests were observed, for an event rate of 8%. ACSM risk stratification did not predict the risk of a positive test. Age, statin use, antiplatelet therapy use, cardiovascular disease, prior treatment with anthracycline or radiation therapy, and being sedentary were predictors of a positive test (all p < .10).

conclusionThe patient risk-stratification profile strongly suggests that the use of formalized preparticipation health screening is required in all oncology scenarios; however, risk of an exercise-induced event is low, suggesting that the use of exercise testing is not required for pre-exercise clearance in the majority of patients.

Indexed as

ExerciseExercise TestAgedCardiovascular SystemElectrocardiographyFemaleHumansMaleMiddle AgedNeoplasmsOxygen ConsumptionPatientsRisk AssessmentAdverse eventsCancerExercise tolerance testingOncologyPre-exercise clearanceSafety

Identifiers

PMID25061091
PMCPMC4153462

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.