Evidence map›Paper›PMID 25061090›Full record

ArticleThe oncologist2014

Type 2 diabetes mellitus is associated with increased mortality in Chinese patients receiving curative surgery for colon cancer.

Kuo-Hsing Chen, Yu-Yun Shao, Zhong-Zhe Lin, Yi-Chun Yeh, Wen-Yi Shau, Raymond Nienchen Kuo, Ho-Min Chen, Chiu-Ling Lai, Kun-Huei Yeh, Ann-Lii Cheng and 1 more

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Article in The oncologist, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Diabetes mellitus and colorectal carcinoma outcomes: a meta-analysis.International journal of colorectal disease · 2020
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  18. Determinants of mortality in patients with type 2 diabetes: a review.Reviews in endocrine & metabolic disorders · 2016
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  20. High Blood Glucose Levels Correlate with Tumor Malignancy in Colorectal Cancer Patients.Medical science monitor : international medical journal of experimental and clinical research · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kuo-Hsing ChenDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Yu-Yun ShaoDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Zhong-Zhe LinDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Yi-Chun YehDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Wen-Yi ShauDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Raymond Nienchen KuoDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Ho-Min ChenDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Chiu-Ling LaiDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Kun-Huei YehDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Ann-Lii ChengDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China.
Mei-Shu LaiDepartment of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin, Taiwan, Republic of China; Department of Oncology and Center for Comparative Effectiveness Research, National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institutes of Oncology and Clinical Medicine and Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China; Institutes of Health Policy and Management and Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, Republic of China mslai@cph.ntu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery.

methodsFrom three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage II colon cancer between January 1, 2004 and December 31, 2008 and had undergone curative surgery. We collected information regarding DM (type 2 DM only), the use of antidiabetic medications, other comorbidities, and survival outcomes. The colon cancer-specific survival (CSS) and the overall survival (OS) were compared between patients with and without DM.

resultsWe selected 6,937 colon cancer patients, among whom 1,371 (19.8%) had DM. The colon cancer patients with DM were older and less likely to receive adjuvant chemotherapy but had a similar tumor stage and grade, compared with colon cancer patients without DM. Compared with colon cancer patients without DM, patients with DM had significantly shorter OS (5-year OS: 71.0% vs. 81.7%) and CSS (5-year CSS: 86.7% vs. 89.2%). After adjusting for age, sex, stage, adjuvant chemotherapy, and comorbidities in our multivariate analysis, DM remained an independent prognostic factor for overall mortality (adjusted hazards ratio: 1.32, 95% confidence interval: 1.18-1.49), but not for cancer-specific mortality. Among the colon cancer patients who had received antidiabetic drug therapy, patients who had used insulin had significantly shorter CSS and OS than patients who had not.

conclusionAmong patients who receive curative surgery for early colon cancer, DM is a predictor of increased overall mortality.

Indexed as

AdultAgedColonic NeoplasmsComorbidityDiabetes Mellitus, Type 2Disease-Free SurvivalFemaleHumansHypoglycemic AgentsMaleMiddle AgedNeoplasm StagingPrognosisTaiwanHypoglycemic AgentsCancer registryColorectal cancerDiabetes mellitusPrognosis

Identifiers

PMID25061090
PMCPMC4153450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.