Evidence map›Paper›PMID 25061059›Full record

ArticleJournal of Parkinson's disease2014

In a rush to decide: deep brain stimulation and dopamine agonist therapy in Parkinson's disease.

Atbin Djamshidian, Sean S O'Sullivan, Alessandro Tomassini, Thomas Foltynie, Patricia Limousin, Iciar Aviles-Olmos, Thomas T Warner, Andrew J Lees, Bruno B Averbeck

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Evidence accumulation in obsessive-compulsive disorder: the role of uncertainty and monetary reward on perceptual decision-making thresholds.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Atbin DjamshidianDepartment of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK Department of Neurology, University Clinic Innsbruck, Tyrol, Austria.
Sean S O'SullivanCork University Hospital, University College Cork, Cork, Ireland.
Alessandro TomassiniSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK.
Thomas FoltynieSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK.
Patricia LimousinSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK.
Iciar Aviles-OlmosSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK.
Thomas T WarnerDepartment of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK.
Andrew J LeesDepartment of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK.
Bruno B AverbeckLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
University of London · GBSobell House · GBUniversity College London · GBNational Institutes of Health · USUniversity College Cork · IE

Funding

Frontal Striatal Systems and Dopamine in Normal and Pathological BehaviorZIAMH002928 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI AVERBECK, BRUNO · 2010 to 2025
$29.0M
Intramural NIH HHS ZIA MH002928
6 · The paper itself

Abstract

backgroundIt has been suggested that all patients with Parkinson's disease (PD) who undergo functional neurosurgery have difficulties in slowing down in high conflict tasks. However, it is unclear whether concomitant dopaminergic medication is responsible for this impairment.

objectiveTo assess perceptual decision making in PD patients with bilateral deep brain stimulation.

methodsWe tested 27 PD patients with bilateral deep brain stimulation on a task in which participants had to filter task relevant information from background noise. Thirteen patients were treated with Levodopa monotherapy and 14 patients were treated with Levodopa in combination with a dopamine agonist. RESULTS were compared to healthy matched controls.

resultsWe found that all PD patients who were treated with a dopamine agonist made faster decisions than controls and PD patients who were not exposed to a dopamine agonist. Further, all patients made more errors than controls, but there was no difference between the two patient groups.

conclusionsOur results suggest that dopamine agonist therapy rather than deep brain stimulation is likely responsible for the inability to slow down in high conflict situations in PD. These results further strengthen the need to reduce dopamine agonists in PD patients undergoing functional neurosurgery in order to prevent them making inadvisable decisions.

Indexed as

AgedAnalysis of VarianceChi-Square DistributionCombined Modality TherapyDeep Brain StimulationDopamine AgonistsFemaleHumansLevodopaMaleMental Status ScheduleMiddle AgedParkinson DiseaseReaction TimeSeverity of Illness IndexSubthalamic NucleusDopamine AgonistsLevodopaDeep brain stimulationdopamine agonistsParkinson's diseaseperceptual decision making

Identifiers

PMID25061059
PMCPMC4256136
OpenAlexW1504905743

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.