SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2015
Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Gothelf's Haplotype of COMT in Parkinson's Disease: A Case-Control Study.Biomedicines · 2026Article
- Does COMT Play a Role in Parkinson's Disease Susceptibility across Diverse Ancestral Populations?Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Addressing the Ethnicity Gap in Catechol O-Methyl Transferase Inhibitor Trials in Parkinson's Disease: A Review of Available Global Data.Journal of personalized medicine · 2024Article
- Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease.Scientific reports · 2020Article
- Gene polymorphisms and motor levodopa-induced complications in Parkinson's disease.Brain and behavior · 2020Article
- Article
- Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease.Translational neurodegeneration · 2017Article
- Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism as an associated risk factor for Parkinson's disease (PD) in Asian rather than Caucasian populations. The aim of this study was to further evaluate the associations of PD risk with COMT polymorphisms in different Asian populations. We carried out a retrieval of studies that investigated associations between COMT Val158Met polymorphism and PD risk in Asians, and included the study if it met the eligibility criteria. Stata version 12.0 was used to analyze the data. A total of 13 studies including 1,834 patients and 2,298 controls were included. The overall result indicated that COMT Val158Met polymorphism was significantly associated with the risk of PD in Asians (AA vs others: OR = 1.58, 95 % CI 1.26-1.97, p < 0.001; GG vs AA: OR = 0.63, 95 % CI 0.47-0.85, p = 0.002; AA vs GA: OR = 1.58, 95 % CI 1.24-2.00, p < 0.001). In Japanese population, the homozygote AA tends to increase the risk of PD (AA vs others: OR = 1.54, 95 % CI 1.10-2.15, p = 0.012; AA vs GA: OR = 1.61, 95 % CI 1.14-2.29, p = 0.008). This study showed that the Val158Met polymorphism of COMT gene may be associated with PD in Japanese rather than Chinese population. Further studies are needed to confirm this association in more ethnicities.
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