Evidence map›Paper›PMID 25060581›Full record

ReviewNature reviews. Immunology2014

Immune modulation by butyrophilins.

Heather A Arnett, Joanne L Viney

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 159 citations in OpenAlex.

  1. Blood transcriptomic signatures distinguishEmerging microbes & infections · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. International journal of molecular sciences · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Domain-Shuffling in the Evolution of Cyclostomes and Gnathostomes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Heather A ArnettDepartment of Inflammation, Amgen, Seattle, Washington, USA.
Joanne L VineyDepartment of Immunology, Biogen Idec, Cambridge, Massachusetts, USA.
Amgen (United States) · USBiogen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The B7 family of co-stimulatory molecules has an important role in driving the activation and inhibition of immune cells. Evolving data have shown that a related family of molecules - the butyrophilins - have similar immunomodulatory functions to B7 family members and may represent a novel subset of co-stimulatory molecules. These studies have taken the field by surprise, as the butyrophilins were previously thought to only be important in lactation and milk production. In this Review, we describe the expression patterns of the various members of the butyrophilin family and explore their immunomodulatory functions. In particular, we emphasize the contribution of butyrophilins to immune homeostasis and discuss the potential of targeting these molecules for therapeutic purposes.

Indexed as

ImmunomodulationAnimalsB7 AntigensButyrophilinsGlycolipidsGlycoproteinsHumansImmunity, InnateLipid DropletsMembrane GlycoproteinsMiceProtein BindingT-LymphocytesB7 AntigensButyrophilinsGlycolipidsGlycoproteinsMembrane Glycoproteinsmilk fat globule

Identifiers

PMID25060581
OpenAlexW2021296394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.