Evidence map›Paper›PMID 25060482›Full record

Trial reportCancer causes & control : CCC2014

Sedentary behavior is associated with colorectal adenoma recurrence in men.

Christine L Sardo Molmenti, Elizabeth A Hibler, Erin L Ashbeck, Cynthia A Thomson, David O Garcia, Denise Roe, Robin B Harris, Peter Lance, Martin Cisneroz, Maria Elena Martinez and 2 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer causes & control : CCC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Polygenic Risk Scores for Follow Up After Colonoscopy and Polypectomy: Another Tool for Risk Stratification and Planning Surveillance?Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Epidemiology and biology of physical activity and cancer recurrence.Journal of molecular medicine (Berlin, Germany) · 2017
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Christine L Sardo MolmentiDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th St., Room 729, New York, NY, 10032, USA, cs3235@columbia.edu.
Elizabeth A Hibler
Erin L Ashbeck
Cynthia A Thomson
David O Garcia
Denise Roe
Robin B Harris
Peter Lance
Martin Cisneroz
Maria Elena Martinez
Patricia A Thompson
Elizabeth T Jacobs
University of Arizona Cancer CenterUniversity of Arizona · USColumbia University · USCritical Path Institute · USUniversity of California, San Diego · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
WHEAT BRAN FIBER SUPPLEMENTS ON THE RECURRENCE OF COLONIC ADENOMASP01CA041108 · NCI · UNIVERSITY OF ARIZONA · PI HAMILTON, STANLEY R. · 1986 to 2009
$38.8M
Cancer Prevention and Control Translational ResearchR25CA078447 · NCI · UNIVERSITY OF ARIZONA · PI ALBERTS, DAVID SAMUEL · 1998 to 2014
$7.6M
Vanderbilt Training Program in Molecular and Genetic Epidemiology of CancerR25CA160056 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, SHU, XIAO-OU · 2012 to 2016
$2.1M
NCI NIH HHS P01 CA041108NCI NIH HHS P30 CA023074NCI NIH HHS P30CA023074NCI NIH HHS PA1CA41108NCI NIH HHS R25 CA078447NCI NIH HHS R25 CA160056
6 · The paper itself

Abstract

purposeThe association between physical activity and colorectal adenoma is equivocal. This study was designed to assess the relationship between physical activity and colorectal adenoma recurrence.

methodsPooled analyses from two randomized, controlled trials included 1,730 participants who completed the Arizona Activity Frequency Questionnaire at baseline, had a colorectal adenoma removed within 6 months of study registration, and had a follow-up colonoscopy during the trial. Logistic regression modeling was employed to estimate the effect of sedentary behavior, light-intensity physical activity, and moderate-vigorous physical activity on colorectal adenoma recurrence.

resultsNo statistically significant trends were found for any activity type and odds of colorectal adenoma recurrence in the pooled population. However, males with the highest levels of sedentary time experienced 47% higher odds of adenoma recurrence. Compared to the lowest quartile of sedentary time, the ORs (95% CIs) for the second, third, and fourth quartiles among men were 1.23 (0.88, 1.74), 1.41 (0.99, 2.01), and 1.47 (1.03, 2.11), respectively (p(trend) = 0.03). No similar association was observed for women.

conclusionsThis study suggests that sedentary behavior is associated with a higher risk of colorectal adenoma recurrence among men, providing evidence of detrimental effects of a sedentary lifestyle early in the carcinogenesis pathway.

Indexed as

Sedentary BehaviorAdenomaAdultAgedAged, 80 and overAge DistributionArizonaClinical Trials, Phase III as TopicColonoscopyColorectal NeoplasmsDouble-Blind MethodFemaleHumansLogistic ModelsMaleMiddle Aged

Identifiers

PMID25060482
PMCPMC4228938
OpenAlexW2078836739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.