ArticleHuman heredity2014
Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.
Article in Human heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis.Medicine · 2020Pooled it
- Heritability of blood pressure traits in diverse populations: a systematic review and meta-analysis.Journal of human hypertension · 2019Pooled it
- Macronutrient-specific effect of theJournal of lipid research · 2018Trial
- Loss of melatonin signaling increases the risk of T2DM caused by metabolic disorders.Cell communication and signaling : CCS · 2025Article
- Structural insights into tRNA recognition of the human FTSJ1-THADA complex.Communications biology · 2025Article
- The influence ofFrontiers in nutrition · 2025Article
- Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency catheter ablation.Journal of geriatric cardiology : JGC · 2024Article
- Association of Vitamin D Receptor Gene Polymorphisms with Cardiometabolic Phenotypes in Hispanics: A Life Course Approach.Nutrients · 2023Article
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- Identification of a Trm732 Motif Required for 2'-ACS omega · 2022Article
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- Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease.International journal of molecular sciences · 2021Review
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- Zinc as a Biomarker of Cardiovascular Health.Frontiers in nutrition · 2021Review
- SNPs in the 3'-untranslated region ofJournal of diabetes and metabolic disorders · 2020Article
- Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.BMC genomics · 2020Article
- PCOS-GWAS Susceptibility Variants inFrontiers in endocrinology · 2020Article
- Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females.BMC medical genetics · 2019Article
- Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample.Metabolic syndrome and related disorders · 2019Article
- Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome.Scientific reports · 2017Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsThe increased occurrence of type 2 diabetes and its clinical correlates is a global public health issue, and there are continued efforts to find its genetic determinant across ethnically diverse populations. The aims of this study were to determine the heritability of diabetes and metabolic syndrome phenotypes in the Arizona Insulin Resistance (AIR) registry and to perform an association analysis of common single nucleotide polymorphisms (SNPs) identified by GWAS with these traits. All study participants were Mexican Americans from the AIR registry.
methodsMetabolic, anthropometric, demographic and medical history information was obtained on the 667 individuals enrolled in the registry.
resultsThe heritability estimates were moderate to high in magnitude and significant, indicating that the AIR registry is well suited for the identification of genetic factors contributing to diabetes and the metabolic syndrome. From the 30 GWAS genes selected (some genes were represented by multiple SNPs), 20 SNPs exhibited associations with one or more of the diabetes related traits with nominal significance (p ≤ 0.05). In addition, 25 SNPs were nominally significantly associated with one or more of the metabolic phenotypes tested (p ≤ 0.05). Most notably, 5 SNPs from 5 genes [body mass index (BMI), hip circumference: rs3751812/FTO; fasting plasma glucose, hemoglobin A1c: rs4607517/GCK; very-low-density lipoprotein: rs10830963/MTNR1B; BMI: rs13266634/SLC30A8, and total cholesterol, low-density lipoprotein: rs7578597/THADA] were significantly associated with obesity, glycemic, and lipid phenotypes when using the multiple testing significance threshold of 0.0015.
conclusionThese findings extend previous work on Mexican Americans to suggest that metabolic disease is strongly influenced by genetic background in this high-risk population.
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