Trial reportJournal of the American College of Cardiology2014
Management practices and major infections after cardiac surgery.
Trial report in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Management Practices and the Risk of Infection Following Cardiac Surgery
Clinical Impact of Rapid Prototyping 3D Models of Congenital Heart Disease on Surgical Management
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Interventions to prevent surgical site infection in adults undergoing cardiac surgery.The Cochrane database of systematic reviews · 2024Pooled it
- Effectiveness of chlorhexidine in preventing infections among patients undergoing cardiac surgeries: a meta-analysis and systematic review.Antimicrobial resistance and infection control · 2021Pooled it
- Maintaining ventilation with very low tidal volume and positive-end expiratory pressure versus no ventilation during cardiopulmonary bypass for cardiac surgery in adults: a randomized clinical trial.Intensive care medicine · 2025Trial
- Care guided by tissue oxygenation and haemodynamic monitoring in off-pump coronary artery bypass grafting (Bottomline-CS): assessor blind, single centre, randomised controlled trial.BMJ (Clinical research ed.) · 2025Trial
- Chlorhexidine-alcohol compared with povidone-iodine-alcohol skin antisepsis protocols in major cardiac surgery: a randomized clinical trial.Intensive care medicine · 2024Trial
- Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.The New England journal of medicine · 2016Trial
- Interhospital variation in Medicare spending for infections after coronary artery bypass grafting and surgical aortic valve replacement.JTCVS open · 2026Article
- Early clinical outcomes of routine prophylactic use of a gentamicin-impregnated sponge in all consecutive patients undergoing cardiac surgical operations: a single-center experience.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2026Article
- Article
- Trends and Impact ofGastroenterology research · 2026Article
- Post-surgical infection in elective cardiac surgeries: what is the role of dental evaluation? A retrospective study.Einstein (Sao Paulo, Brazil) · 2026Article
- Association between time-weighted average lactate during cardiopulmonary bypass and postoperative infection in patients undergoing cardiac surgery: single-center, prospective cohort study protocol.Frontiers in cardiovascular medicine · 2026Article
- Disparities in 180-day infection rates following coronary artery bypass grafting and aortic valve replacement.The Journal of thoracic and cardiovascular surgery · 2025Article
- A retrospective case-control study of a cluster of surgical site infections after coronary artery bypass grafting at a tertiary medical center.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Coronary artery bypass grafting in patients with hematological neoplasms.Frontiers in cardiovascular medicine · 2025Article
- Article
- Association of adherence to individual components of Society of Thoracic Surgeons cardiac surgery antibiotic guidelines and postoperative infections.The Journal of thoracic and cardiovascular surgery · 2024Observational
- A nomogram predicting pneumonia after cardiac surgery: a retrospective modeling study.Journal of cardiothoracic surgery · 2024Article
- Epidemiology and Risk Factors for Nosocomial Infections in Left Ventricular Assist Device Recipients.Life (Basel, Switzerland) · 2024Article
- Post-operative infections after cardiothoracic surgery and vascular procedures: a bibliometric and visual analysis of the 100 most-cited articles in the past 2 decades.GMS hygiene and infection control · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors at 15 institutions in 2 countries.
Funding
Abstract
backgroundInfections are the most common noncardiac complication after cardiac surgery, but their incidence across a broad range of operations, as well as the management factors that shape infection risk, remain unknown.
objectivesThis study sought to prospectively examine the frequency of post-operative infections and associated mortality, and modifiable management practices predictive of infections within 65 days from cardiac surgery.
methodsThis study enrolled 5,158 patients and analyzed independently adjudicated infections using a competing risk model (with death as the competing event).
resultsNearly 5% of patients experienced major infections. Baseline characteristics associated with increased infection risk included chronic lung disease (hazard ratio [HR]: 1.66; 95% confidence interval [CI]: 1.21 to 2.26), heart failure (HR: 1.47; 95% CI: 1.11 to 1.95), and longer surgery (HR: 1.31; 95% CI: 1.21 to 1.41). Practices associated with reduced infection risk included prophylaxis with second-generation cephalosporins (HR: 0.70; 95% CI: 0.52 to 0.94), whereas post-operative antibiotic duration >48 h (HR: 1.92; 95% CI: 1.28 to 2.88), stress hyperglycemia (HR: 1.32; 95% CI: 1.01 to 1.73); intubation time of 24 to 48 h (HR: 1.49; 95% CI: 1.04 to 2.14); and ventilation >48 h (HR: 2.45; 95% CI: 1.66 to 3.63) were associated with increased risk. HRs for infection were similar with either <24 h or <48 h of antibiotic prophylaxis. There was a significant but differential effect of transfusion by surgery type (excluding left ventricular assist device procedures/transplant) (HR: 1.13; 95% CI: 1.07 to 1.20). Major infections substantially increased mortality (HR: 10.02; 95% CI: 6.12 to 16.39).
conclusionsMajor infections dramatically affect survival and readmissions. Second-generation cephalosporins were strongly associated with reduced major infection risk, but optimal duration of antibiotic prophylaxis requires further study. Given practice variations, considerable opportunities exist for improving outcomes and preventing readmissions. (Management Practices and Risk of Infection Following Cardiac Surgery; NCT01089712).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.