ArticleScientific reports2014
TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds.Journal of advanced research · 2024Article
- A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.The Journal of experimental medicine · 2021Article
- Computational flow cytometric analysis to detect epidermal subpopulations in human skin.Biomedical engineering online · 2021Article
- Autocrine and Paracrine Effects of Vascular Endothelial Cells Promote Cutaneous Wound Healing.BioMed research international · 2021Article
- Development and Maintenance of Epidermal Stem Cells in Skin Adnexa.International journal of molecular sciences · 2020Review
- Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes.European journal of medicinal chemistry · 2020Review
- Circadian control of interferon-sensitive gene expression in murine skin.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Co-Expression Pattern of p63 and HDAC1: A Potential Way to Disclose Stem Cells in Interfollicular Epidermis.International journal of molecular sciences · 2017Article
- Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.Genome medicine · 2017Article
- The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normal interfollicular epidermis (IFE) homeostasis is maintained throughout the entire life by its own stem cells that self-renew and generate progeny that undergo terminal differentiation. However, the fine markers of the stem cells in interfollicular epidermis are not well defined yet. Here we found that TLR7 identified the existence of progenitors and interfollicular epidermal stem cells in murine skin. In vitro, TLR7-expressing cells comprised of two subpopulations that were competent to proliferate and exhibited distinct differentiation potentials. Three-dimensional (3D) organotypic culture and skin reconstitution assays showed that TLR7-expressing cells were able to reconstruct the interfollicular epidermis. Finally, TLR7-expressing cells maintained the intact interfollicular epidermal structures revealed in serial transplantation assays in vivo in mice. Taken together, our results suggest that TLR7-expressing cells comprise an interfollicular epidermal stem cell population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.