ArticleBehavior genetics2014
Resolving the effects of maternal and offspring genotype on dyadic outcomes in genome wide complex trait analysis ("M-GCTA").
Article in Behavior genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.Translational psychiatry · 2021Pooled it
- Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy.PLoS genetics · 2020Pooled it
- Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.Nature genetics · 2019Pooled it
- Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.Human molecular genetics · 2017Pooled it
- Pooled it
- Admixture mapping identifies African and Amerindigenous local ancestry loci associated with fetal growth.Human genetics · 2021Trial
- Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth.Epigenetics · 2026Article
- Article
- Indirect genetic effects of siblings.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Multivariate maternal effects across the internalizing-externalizing spectrum in childhood: results from the Norwegian mother, father, and child cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Direct and Indirect Genetic Effects on Child ADHD Traits in Early and Mid-Childhood: Trio Genome-Wide Complex Trait Analyses in a Large Norwegian Birth Registry Cohort.Behavior genetics · 2026Article
- Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways.Diabetologia · 2026Article
- Genomic approaches to understanding pregnancy phenotypes and birth outcomes and their links with long-term maternal and offspring health-the value of distinguishing maternal and fetal genetic effects.Frontiers in genetics · 2026Review
- A bespoke non-invasive approach to predict fetal genotype in pregnancy.Frontiers in medicine · 2026Article
- Intergenerational transmission of complex traits and the offspring methylome.Molecular psychiatry · 2025Article
- Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes.PLoS genetics · 2025Article
- Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.Clinics in perinatology · 2024Review
- Interpreting population- and family-based genome-wide association studies in the presence of confounding.PLoS biology · 2024Article
- Heritability Estimation of Cognitive Phenotypes in the ABCD StudyBehavior genetics · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Genome wide complex trait analysis (GCTA) is extended to include environmental effects of the maternal genotype on offspring phenotype ("maternal effects", M-GCTA). The model includes parameters for the direct effects of the offspring genotype, maternal effects and the covariance between direct and maternal effects. Analysis of simulated data, conducted in OpenMx, confirmed that model parameters could be recovered by full information maximum likelihood (FIML) and evaluated the biases that arise in conventional GCTA when indirect genetic effects are ignored. Estimates derived from FIML in OpenMx showed very close agreement to those obtained by restricted maximum likelihood using the published algorithm for GCTA. The method was also applied to illustrative perinatal phenotypes from ~4,000 mother-offspring pairs from the Avon Longitudinal Study of Parents and Children. The relative merits of extended GCTA in contrast to quantitative genetic approaches based on analyzing the phenotypic covariance structure of kinships are considered.
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