ArticleNeuroradiology2014
Minimal hepatic encephalopathy in children with liver cirrhosis: diffusion-weighted MR imaging and proton MR spectroscopy of the brain.
Article in Neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Calcium channelopathies and intellectual disability: a systematic review.Orphanet journal of rare diseases · 2021Pooled it
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- Hepatic encephalopathy in non-cirrhotic portal hypertension.Metabolic brain disease · 2025Review
- Metabolic alterations within the primary visual cortex in blind patients with end-stage glaucoma: a proton magnetic resonance spectroscopy study.Frontiers in cell and developmental biology · 2025Article
- Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset.Metabolic brain disease · 2023Article
- The added value of brain MR spectroscopy in children with Crigler-Najjar syndrome type-I: correlation with demographic, neurodevelopmental, and laboratory findings.The British journal of radiology · 2023Article
- Determination of Turkish norms of psychometric tests for diagnosing minimal hepatic encephalopathy and proposal of a high sensitive screening test battery.Hepatology international · 2021Article
- Prediction of minimal hepatic encephalopathy by using an radiomics nomogram in chronic hepatic schistosomiasis patients.PLoS neglected tropical diseases · 2021Article
- Severe asterixis due to hypermagnesemia in chronic renal failure: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Neurobehavioral recovery in patients who emerged from prolonged disorder of consciousness: a retrospective study.BMC neurology · 2020Observational
- Multi-parametric arterial spin labelling and diffusion-weighted magnetic resonance imaging in differentiation of grade II and grade III gliomas.Polish journal of radiology · 2020Article
- Quality of life in patients with minimal hepatic encephalopathy.World journal of gastroenterology · 2018Review
- Diffusion tensor imaging of the optic disc in idiopathic intracranial hypertension.Neuroradiology · 2018Article
- Observational
- Magnetic resonance spectroscopy of the frontal region in patients with metabolic syndrome: correlation with anthropometric measurement.Polish journal of radiology · 2018Article
- Globus pallidus MR signal abnormalities in children with chronic liver disease and/or porto-systemic shunting.European radiology · 2017Article
- Quantitative magnetic resonance imaging in patients with cirrhosis: a cross-sectional study.Metabolic brain disease · 2016Article
- Magnetic Resonance Spectroscopy for Evaluating Portal-Systemic Encephalopathy in Patients with Chronic Hepatic Schistosomiasis Japonicum.PLoS neglected tropical diseases · 2016Article
- PET and MR imaging of neuroinflammation in hepatic encephalopathy.Metabolic brain disease · 2015Review
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this work was to detect minimal hepatic encephalopathy (minHE) in children with diffusion-weighted MR imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) of the brain.
methodsProspective study conducted upon 30 consecutive children (age range 6-16 years, 21 boys and 9 girls) with liver cirrhosis and 15 age- and sex-matched healthy control children. Patients with minHE (n = 17) and with no minHE (n = 13) groups and control group underwent DWI, 1H-MRS, and neuropsychological tests (NPTs). The glutamate or glutamine (Glx), myoinositol (mI), choline (Cho), and creatine (Cr) at the right ganglionic region were determined at 1H-MRS. The apparent diffusion coefficient (ADC) value and metabolic ratios of Glx/Cr, mI/Cr, and Cho/Cr were calculated.
resultsThere was elevated ADC value and Glx/Cr and decreased mI/CI and Ch/Cr in patients with minHE compared to no minHE and control group. There was significant difference between minHE, no minHE, and control group in the ADC value (P = 0.001 for all groups), GLx/Cr (P = 0.001 for all groups), mI/Cr (P = 0.004, 0.001, and 0.001, respectively), Ch/Cr (P = 0.001 for all groups), and full-scale IQ of NPT (P = 0.001, 0.001, and 0.143, respectively). The NPT of minHE had negative correlation with ADC value (r = -0.872, P = 0.001) and GLx/Cr (r = -0.812, P = 0.001) and positive correlation with mI/Cr (r = 0.732, P = 0.001).
conclusionDWI and 1H-MRS are imaging modalities that can detect minHE in children with liver cirrhosis and correlate well with parameters of NPT.
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