ArticleBMJ open2014
Assessing the association of oxytocin augmentation with obstetric anal sphincter injury in nulliparous women: a population-based, case-control study.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mediolateral/lateral episiotomy with operative vaginal delivery and the risk reduction of obstetric anal sphincter injury (OASI): A systematic review and meta-analysis.International urogynecology journal · 2022Pooled it
- Perineal techniques during the second stage of labour for reducing perineal trauma.The Cochrane database of systematic reviews · 2017Pooled it
- The effect of intravenous hyoscine butylbromide on slow progress in labor (BUSCLAB): A double-blind randomized placebo-controlled trial.PLoS medicine · 2024Trial
- De-medicalization of birth by reducing the use of oxytocin for augmentation among first-time mothers - a prospective intervention study.BMC pregnancy and childbirth · 2018Trial
- Prevention of obstetric anal sphincter injuries with perineal support and lateral episiotomy: A historical cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Tools for establishing a sustainable safety culture within maternity services. A retrospective case study.SAGE open medicine · 2023Article
- Article
- Intact Perineum: What are the Predictive Factors in Spontaneous Vaginal Birth?Materia socio-medica · 2019Article
- Duration of second stage of labor and instrumental delivery as risk factors for severe perineal lacerations: population-based study.BMC pregnancy and childbirth · 2017Article
- Perineal injuries and birth positions among 2992 women with a low risk pregnancy who opted for a homebirth.BMC pregnancy and childbirth · 2016Article
- Obstetric anal sphincter injuries: review of anatomical factors and modifiable second stage interventions.International urogynecology journal · 2015Review
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Authors and funding
4 authors.
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Abstract
objectiveTo assess the association of oxytocin augmentation with obstetric anal sphincter injury among nulliparous women.
designPopulation-based, case-control study.
settingPrimary and secondary teaching hospital serving a Norwegian region. POPULATION: 15 476 nulliparous women with spontaneous start of labour, single cephalic presentation and gestation ≥37 weeks delivering vaginally between 1999 and 2012.
methodsBased on the presence or absence of oxytocin augmentation, episiotomy, operative vaginal delivery and birth weight (<4000 vs ≥4000 g), we modelled in logistic regression the best fit for prediction of anal sphincter injury. Within the modified model of main exposures, we tested for possible confounding, and interactions between maternal age, ethnicity, occiput posterior position and epidural analgaesia.
main outcome measureObstetric anal sphincter injury.
resultsOxytocin augmentation was associated with a higher OR of obstetric anal sphincter injuries in women giving spontaneous birth to infants weighing <4000 g (OR 1.8; 95% CI 1.5 to 2.2). Episiotomy was not associated with sphincter injuries in spontaneous births, but with a lower OR in operative vaginal deliveries. Spontaneous delivery of infants weighing ≥4000 g was associated with a threefold higher OR, and epidural analgaesia was associated with a 30% lower OR in comparison to no epidural analgaesia.
conclusionsOxytocin augmentation was associated with a higher OR of obstetric anal sphincter injuries during spontaneous deliveries of normal-size infants. We observed a considerable effect modification between the most important factors predicting anal sphincter injuries in the active second stage of labour.
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