ArticleDevelopmental neurobiology2015
Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function.
Article in Developmental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Confronting the loss of trophic support.Frontiers in molecular neuroscience · 2023Article
- Review
- Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor.Frontiers in molecular neuroscience · 2022Article
- Review
- Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network.Frontiers in neuroscience · 2021Article
- Age Related Response of Neonatal Rat Retinal Ganglion Cells to Reduced TrkB SignalingFrontiers in cell and developmental biology · 2021Article
- Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer.International journal of molecular sciences · 2020Review
- Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology.Neurobiology of disease · 2019Article
- Stingless Bee Honey Improves Spatial Memory in Mice, Probably Associated with Brain-Derived Neurotrophic Factor (BDNF) and Inositol 1,4,5-Triphosphate Receptor Type 1 (Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.Cellular and molecular neurobiology · 2018Review
- Application of the Co-culture Membrane System Pointed to a Protective Role of Catestatin on Hippocampal Plus Hypothalamic Neurons Exposed to Oxygen and Glucose Deprivation.Molecular neurobiology · 2017Article
- Daily supplementation with GrandFusionAging · 2017Article
- In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival.Pharmaceutical research · 2017Article
- Neurotrophin signalling: novel insights into mechanisms and pathophysiology.Clinical science (London, England : 1979) · 2017Review
- APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study.Experimental gerontology · 2017Article
- Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease.Neurobiology of disease · 2017Review
- Tau-Driven Neuronal and Neurotrophic Dysfunction in a Mouse Model of Early Tauopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp.Cell reports · 2015Article
- Rare variants in the neurotrophin signaling pathway implicated in schizophrenia risk.Schizophrenia research · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Neurotrophins play a crucial role in mediating neuronal survival and synaptic plasticity. A lack of trophic factor support in the peripheral nervous system (PNS) is associated with a transcription-dependent programmed cell death process in developing sympathetic neurons. While most of the attention has been on events culminating in cell death in the PNS, the earliest events that occur after trophic factor withdrawal in the central nervous system (CNS) have not been investigated. In the CNS, brain-derived neurotrophic factor (BDNF) is widely expressed and is released in an activity-dependent manner to shape the structure and function of neuronal populations. Reduced neurotrophic factor support has been proposed as a mechanism to account for changes in synaptic plasticity during neurodevelopment to aging and neurodegenerative disorders. To this end, we performed transcriptional profiling in cultured rat hippocampal neurons. We used a TrkB ligand scavenger (TrkB-FC ) to sequester endogenous neurotrophic factor activity from hippocampal neurons in culture. Using a high-density microarray platform, we identified a significant decrease in genes that are associated with vesicular trafficking and synaptic function, as well as selective increases in MAP kinase phosphatases. A comparison of these changes with recent studies of Alzheimer's disease and cognitive impairment in postmortem brain tissue revealed striking similarities in gene expression changes for genes involved in synaptic function. These changes are relevant to a wide number of conditions in which levels of BDNF are compromised.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.