ArticleNature communications2014
Diverse and divergent protein post-translational modifications in two growth stages of a natural microbial community.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The microbiologist's guide to metaproteomics.iMeta · 2025Review
- The Role of Heat Shock Protein (Hsp) Chaperones in Environmental Stress Adaptation and Virulence of Plant Pathogenic Bacteria.International journal of molecular sciences · 2025Review
- FISH-Flow Cytometry Reveals Microbiome-Wide Changes in Post-Translational Modification and Altered Microbial Abundance Among Children with Inflammatory Bowel Disease.Pathogens (Basel, Switzerland) · 2024Article
- A Review on the Interaction of Acetic Acid Bacteria and Microbes in Food Fermentation: A Microbial Ecology Perspective.Foods (Basel, Switzerland) · 2024Review
- Plant Growth-Promoting Bacteria of Soil: Designing of Consortia Beneficial for Crop Production.Microorganisms · 2023Review
- Frequency of change determines effectiveness of microbial response strategies.The ISME journal · 2023Article
- Article
- Rational engineering of adeno-associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity.Cell proliferation · 2022Article
- Metaproteomics reveals insights into microbial structure, interactions, and dynamic regulation in defined communities as they respond to environmental disturbance.BMC microbiology · 2021Article
- Recent progress in the application of omics technologies in the study of bio-mining microorganisms from extreme environments.Microbial cell factories · 2021Review
- The expression of the acarbose biosynthesis gene cluster in Actinoplanes sp. SE50/110 is dependent on the growth phase.BMC genomics · 2020Article
- Review
- Post-translational modifications in capsid proteins of recombinant adeno-associated virus (AAV) 1-rh10 serotypes.The FEBS journal · 2019Article
- Comparative proteomics of stenotopic caddisfly Crunoecia irrorata identifies acclimation strategies to warming.Molecular ecology · 2019Article
- Mediterranean grassland soil C-N compound turnover is dependent on rainfall and depth, and is mediated by genomically divergent microorganisms.Nature microbiology · 2019Article
- Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology.Trends in biotechnology · 2019Review
- Genome-Resolved Proteomic Stable Isotope Probing of Soil Microbial Communities UsingFrontiers in microbiology · 2019Article
- Capacity for instantaneous catabolism of preferred and non-preferred carbon sources in Escherichia coli and Bacillus subtilis.Scientific reports · 2018Article
- Sipros Ensemble improves database searching and filtering for complex metaproteomics.Bioinformatics (Oxford, England) · 2018Article
- Maternal consumption of fish oil programs reduced adiposity in broiler chicks.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Detailed characterization of post-translational modifications (PTMs) of proteins in microbial communities remains a significant challenge. Here we directly identify and quantify a broad range of PTMs (hydroxylation, methylation, citrullination, acetylation, phosphorylation, methylthiolation, S-nitrosylation and nitration) in a natural microbial community from an acid mine drainage site. Approximately 29% of the identified proteins of the dominant Leptospirillum group II bacteria are modified, and 43% of modified proteins carry multiple PTM types. Most PTM events, except S-nitrosylations, have low fractional occupancy. Notably, PTM events are detected on Cas proteins involved in antiviral defense, an aspect of Cas biochemistry not considered previously. Further, Cas PTM profiles from Leptospirillum group II differ in early versus mature biofilms. PTM patterns are divergent on orthologues of two closely related, but ecologically differentiated, Leptospirillum group II bacteria. Our results highlight the prevalence and dynamics of PTMs of proteins, with potential significance for ecological adaptation and microbial evolution.
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