ArticleJournal of community genetics2015
Haemoglobinopathies in eastern Indian states: a demographic evaluation.
Article in Journal of community genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors.Transplantation · 2017Guideline
- Thalassemia and hemoglobinopathy prevalence in a community-based sample in Sylhet, Bangladesh.Orphanet journal of rare diseases · 2023Trial
- α-Thalassemia in Oraons-indigenous tribal population from Jharkhand, India: insights to common deletions.Human genetics · 2026Article
- Article
- Sickle Cell Disease in Eastern Uttar Pradesh, India: Sociodemographic and Clinical Profile from a Previously Undocumented Area.Journal of racial and ethnic health disparities · 2026Article
- Mutation Analysis for Hemoglobinopathies in Eastern Jharkhand.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Assessing NESTROFT as a preliminary screening tool for thalassemia in the Malayali tribes of Dharmapuri district, Tamil Nadu, India.Journal of family medicine and primary care · 2024Article
- Prevalence of beta thalassemia carriers in India: a systematic review and meta-analysis.Journal of community genetics · 2023Review
- Systematic Literature Review Shows Gaps in Data on Global Prevalence and Birth Prevalence of Sickle Cell Disease and Sickle Cell Trait: Call for Action to Scale Up and Harmonize Data Collection.Journal of clinical medicine · 2023Review
- Profile of Hemoglobin D (HbD) Disease in Eastern Uttar Pradesh: A Single-Center Experience.Cureus · 2022Article
- Nationwide carrier detection and molecular characterization of β-thalassemia and hemoglobin E variants in Bangladeshi population.Orphanet journal of rare diseases · 2020Article
- Multiple micronutrient status and predictors of anemia in young children aged 12-23 months living in New Delhi, India.PloS one · 2019Article
- Prenatal Diagnosis of HbE-β-Thalassemia: Experience of a Center in Western India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2018Article
- A Large Cohort Study of Genotype and Phenotype Correlations of Beta- Thalassemia in Iranian Population.International journal of hematology-oncology and stem cell research · 2015Article
- Diversity of sickle cell trait in Jharkhand state in India: Is it the zone of contact between two geographically and ethnically distinct populations in India?Journal of biosciences · 2015Article
- The Burden of Thalassemia and Various Hemoglobinopathies in Bihar: Trends and Patterns.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
- Sickle cells are not necessarily protective against falciparum- A case report.Asian journal of transfusion scienceArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemoglobinopathies are a leading cause of child mortality worldwide, although with a variable geographical incidence. A reliable estimate of prevalence of the disease is necessary for reducing its burden. However, most studies in India are either hospital based or from certain regions of the country and hence may not realistically reflect the disease burden. The eastern Indian states of Bihar, Chhattisgarh and Jharkhand and eastern region of Uttar Pradesh, which comprise ~25 % population of the country, are poorly studied with respect to haemoglobinopathies. The present study, conducted on 1,642 individuals from this region, shows a frequency of 3.4 % for β-thalassaemia trait (BTT), 3.4 % for sickle cell haemoglobin trait (HbS)/haemoglobin E trait (HbE) and 18 % for α-globin defects. While BTT mutations are distributed rather uniformly across the region, HbS occurs only in Chhattisgarh and Jharkhand, the regions rich in tribal populations. The frequency of α-gene mutation is strikingly high, occurring even in individuals with normal blood count, in tribal as well as non-tribal groups. The mutation spectrum of BTT is also distinct since the common mutations, IVS1-1 (G-T) and 619 bp del, are absent while CD15 (G-A) is the second most frequent. The HbA2 level in the suspected cases is strikingly low. We demonstrate association of the low HbA2 level with vitamin B12 and folate deficiency in this cohort. Thus, the present report besides providing an estimate of the carrier frequency of β-thalassaemia traits also confirms high prevalence of α-gene defects and regional heterogeneity in distribution of HbS in the eastern parts of India.
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Registered trials
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