ReviewJournal of neural transmission (Vienna, Austria : 1996)2014
Elucidating the neurophysiological underpinnings of autism spectrum disorder: new developments.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Face Recognition and Visual Search Strategies in Autism Spectrum Disorders: Amending and Extending a Recent Review by Weigelt et al.PloS one · 2015Pooled it
- Autism Spectrum Disorder with Epilepsy: A Research Protocol for a Clinical and Genetic Study.Genes · 2023Article
- Severely Attenuated Visual Feedback Processing in Children on the Autism Spectrum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Autism classified by magnetic resonance imaging: A pilot study of a potential diagnostic tool.International journal of methods in psychiatric research · 2020Article
- Psychiatric comorbidities in Asperger syndrome are related with polygenic overlap and differ from other Autism subtypes.Translational psychiatry · 2020Article
- Fast Periodic Visual Stimulation EEG Reveals Reduced Neural Sensitivity to Fearful Faces in Children with Autism.Journal of autism and developmental disorders · 2019Article
- Functional brain connectivity in a rodent seizure model of autistic-like behavior.Epilepsy & behavior : E&B · 2019Article
- Late Positive Potential ERP Responses to Social and Nonsocial Stimuli in Youth with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2016Article
- Advancing the understanding of autism disease mechanisms through genetics.Nature medicine · 2016Review
- Epilepsy and Autism.Cold Spring Harbor perspectives in medicine · 2016Review
- Opposing effects of glutamatergic and GABAergic pharmacological manipulations on a visual perception task with relevance to schizophrenia.Psychopharmacology · 2015Article
- Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide.Neurobiology of disease · 2015Article
- A Concise History of Asperger Syndrome: The Short Reign of a Troublesome Diagnosis.Frontiers in psychology · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of neurophysiological approaches together with rare and common risk factors for Autism Spectrum Disorder (ASD) allows elucidating the specific underlying neurobiology of ASD. Whereas most neurophysiologically based research in ASD to date has focussed on case-control differences based on the DSM- or ICD-based categorical ASD diagnosis, more recent studies have aimed at studying genetically and/or neurophysiologically defined homogeneous ASD subgroups for specific neuronal biomarkers. This review addresses the neurophysiological investigation of ASD by evoked and event-related potentials, by EEG/MEG connectivity measures such as coherence, and transcranial magnetic stimulation. As an example of classical neurophysiological studies in ASD, we report event-related potential studies which have illustrated which brain areas and processing stages are affected in the visual perception of socially relevant stimuli. However, a paradigm shift has taken place in recent years focussing on how these findings can be tracked down to basic neuronal functions such as deficits in cortico-cortical connectivity and the interaction between brain areas. Disconnectivity, for example, can again be related to genetically induced shifts in the excitation/inhibition balance. Genetic causes of ASD may be grouped by their effects on the brain's system level to identify ASD subgroups which respond differentially to therapeutic interventions.
Indexed as
Identifiers
25059455What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.