Evidence map›Paper›PMID 25059239›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014

Structural remodeling of coronary resistance arteries: effects of age and exercise training.

Mina A Hanna, Curtis R Taylor, Bei Chen, Hae-Sun La, Joshua J Maraj, Cody R Kilar, Bradley J Behnke, Michael D Delp, Judy M Muller-Delp

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
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  9. Article
  10. Coronary microvascular adaptations distal to epicardial artery stenosis.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  11. Coronary remodeling and biomechanics: Are we going with the flow in 2020?American journal of physiology. Heart and circulatory physiology · 2021
    Review
  12. Review
  13. Article
  14. Proinflammation, profibrosis, and arterial aging.Aging medicine (Milton (N.S.W)) · 2020
    Review
  15. Article
  16. Age-Related Impairment of Structure and Function of Iliac Artery Endothelium in Rats Is Improved by Elevated Fluid Shear Stress.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mina A HannaDepartment of Materials Science and Engineering, University of Florida, Gainesville, Florida; Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida; Department of Materials Science and Engineering, Stanford University, Stanford, California.
Curtis R TaylorDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida;
Bei ChenDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida;
Hae-Sun LaDepartment of Materials Science and Engineering, University of Florida, Gainesville, Florida;
Joshua J MarajDepartment of Materials Science and Engineering, University of Florida, Gainesville, Florida;
Cody R KilarDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida;
Bradley J BehnkeDepartment of Applied Physiology and Kinesiology and the Center for Exercise Science, University of Florida, Gainesville, Florida;
Michael D DelpDepartment of Applied Physiology and Kinesiology and the Center for Exercise Science, University of Florida, Gainesville, Florida;
Judy M Muller-DelpDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, Florida; judy.delp@med.fsu.edu.
University of Florida · USStanford University · US

Funding

Aging, Estrogen, and Coronary Endothelial FunctionR01HL077224 · NHLBI · WEST VIRGINIA UNIVERSITY · PI DELP, JUDY M · 2005 to 2008
$1.4M
Microvascular Aging and eNOS UncouplingR01HL090937 · NHLBI · UNIVERSITY OF FLORIDA · PI DELP, JUDY M, WYSOLMERSKI, ROBERT B. · 2009 to 2010
$825k
NHLBI NIH HHS R01 HL090937NHLBI NIH HHS R01-HL-77224NHLBI NIH HHS R01-HL-90937
6 · The paper itself

Abstract

Age is known to induce remodeling and stiffening of large-conduit arteries; however, little is known of the effects of age on remodeling and mechanical properties of coronary resistance arteries. We employed a rat model of aging to investigate whether 1) age increases wall thickness and stiffness of coronary resistance arteries, and 2) exercise training reverses putative age-induced increases in wall thickness and stiffness of coronary resistance arteries. Young (4 mo) and old (21 mo) Fischer 344 rats remained sedentary or underwent 10 wk of treadmill exercise training. Coronary resistance arteries were isolated for determination of wall-to-lumen ratio, effective elastic modulus, and active and passive responses to changes in intraluminal pressure. Elastin and collagen content of the vascular wall were assessed histologically. Wall-to-lumen ratio increased with age, but this increase was reversed by exercise training. In contrast, age reduced stiffness, and exercise training increased stiffness in coronary resistance arteries from old rats. Myogenic responsiveness was reduced with age and restored by exercise training. Collagen-to-elastin ratio (C/E) of the wall did not change with age and was reduced with exercise training in arteries from old rats. Thus age induces hypertrophic remodeling of the vessel wall and reduces the stiffness and myogenic function of coronary resistance arteries. Exercise training reduces wall-to-lumen ratio, increases wall stiffness, and restores myogenic function in aged coronary resistance arteries. The restorative effect of exercise training on myogenic function of coronary resistance arteries may be due to both changes in vascular smooth muscle phenotype and expression of extracellular matrix proteins.

Indexed as

AgingAnimalsCollagenCoronary VesselsElastinIn Vitro TechniquesMaleMuscle ContractionNanotechnologyPhysical Conditioning, AnimalRatsRats, Inbred F344Vascular ResistanceVascular StiffnessCollagenElastinelastic modulushypertrophynanoindentationvan GeisonVerhoeff

Identifiers

PMID25059239
PMCPMC4157167
OpenAlexW2060300222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.