Trial reportThe journal of sexual medicine2014
Sexual bother in men with advanced prostate cancer undergoing androgen deprivation therapy.
Trial report in The journal of sexual medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The effects of resistance exercise on physical performance and health-related quality of life in prostate cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Pooled it
- Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme.Lancet (London, England) · 2021Trial
- Salvage Androgen Deprivation Therapy Use After Definitive Radiotherapy With vs Without Androgen Deprivation Therapy in Prostate Cancer.The Prostate · 2026Article
- Toxicity and patient-reported outcomes after moderately hypofractionated radiotherapy (60 Gy in 20 fractions) for prostate cancer: prospective observational study.Journal of radiation research · 2025Observational
- Sexual distress among men with cancer - a cross-sectional study.Acta oncologica (Stockholm, Sweden) · 2025Article
- Impact of neoadjuvant relugolix on patient-reported sexual function and bother.Frontiers in oncology · 2024Article
- Sexual characteristics of patients with prostate cancer seen for radiation treatment.Ecancermedicalscience · 2023Article
- The impact of hegemonic masculine ideals on self-esteem in prostate cancer patients undergoing androgen deprivation therapy (ADT) compared to ADT-naïve patients.Psycho-oncology · 2022Article
- Psychosocial Aspects of Living Long Term with Advanced Cancer and Ongoing Systemic Treatment: A Scoping Review.Cancers · 2022Article
- Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy.Journal of behavioral medicine · 2022Article
- Sexual function in men undergoing androgen deprivation therapy.International journal of impotence research · 2021Review
- On the Relationship Between Erectile Function and Sexual Distress in Men with Prostate Cancer.Archives of sexual behavior · 2020Article
- Estimating utilities/disutilities for high-risk metastatic hormone-sensitive prostate cancer (mHSPC) and treatment-related adverse events.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Review
- Mood, sexuality, and relational intimacy after starting androgen deprivation therapy: implications for couples.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Effect of androgen deprivation therapy on sexual function and bother in men with prostate cancer: A controlled comparison.Psycho-oncology · 2018Article
- Quality of life worsened the most severely in patients immediately after intensity-modulated radiotherapy for prostate cancer.Research and reports in urology · 2018Article
- The Effect of Targeted Therapy for Genitourinary Malignancies on Sexual Function and Fertility.Current urology reports · 2017Review
- The use of exercise interventions to overcome adverse effects of androgen deprivation therapy.Nature reviews. Urology · 2016Review
- The primary health care physician and the cancer patient: tips and strategies for managing sexual health.Translational andrology and urology · 2015Review
- Prostatic irradiation-induced sexual dysfunction: a review and multidisciplinary guide to management in the radical radiotherapy era (Part I defining the organ at risk for sexual toxicities).Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 3 countries.
Funding
Abstract
introductionMen with advanced prostate cancer (APC) undergoing androgen deprivation therapy (ADT) often experience distressing sexual side effects. Sexual bother is an important component of adjustment. Factors associated with increased bother are not well understood.
aimsThis study sought to describe sexual dysfunction and bother in APC patients undergoing ADT, identify socio-demographic and health/disease-related characteristics related to sexual bother, and evaluate associations between sexual bother and psychosocial well-being and quality of life (QOL).
methodsBaseline data of a larger psychosocial intervention study was used. Pearson's correlation and independent samples t-test tested bivariate relations. Multivariate regression analysis evaluated relations between sexual bother and psychosocial and QOL outcomes.
main outcome measuresThe Expanded Prostate Cancer Index Composite sexual function and bother subscales, Center for Epidemiologic Studies Depression Scale, Functional Assessment of Cancer Therapy--General, and Dyadic Adjustment Scale were the main outcome measures.
resultsParticipants (N = 80) were 70 years old (standard deviation [SD] = 9.6) and reported 18.7 months (SD = 17.3) of ADT. Sexual dysfunction (mean = 10.1; SD = 18.0) was highly prevalent. Greater sexual bother (lower scores) was related to younger age (β = 0.25, P = 0.03) and fewer months of ADT (β = 0.22, P = 0.05). Controlling for age, months of ADT, current and precancer sexual function, sexual bother correlated with more depressive symptoms (β = -0.24, P = 0.06) and lower QOL (β = 0.25, P = 0.05). Contrary to hypotheses, greater sexual bother was related to greater dyadic satisfaction (β = -0.35, P = 0.03) and cohesion (β = -0.42, P = 0.01).
conclusionsThe majority of APC patients undergoing ADT will experience sexual dysfunction, but there is variability in their degree of sexual bother. Psychosocial aspects of sexual functioning should be considered when evaluating men's adjustment to ADT effects. Assessment of sexual bother may help identify men at risk for more general distress and lowered QOL. Psychosocial interventions targeting sexual bother may complement medical treatments for sexual dysfunction and be clinically relevant, particularly for younger men and those first starting ADT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.