ArticlePloS one2014
The expanded diversity of methylophilaceae from Lake Washington through cultivation and genomic sequencing of novel ecotypes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 82 citations in OpenAlex.
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- Proteomic evidence for aerobic methane production in groundwater by methylotrophic Methylotenera.The ISME journal · 2025Article
- Identifying microbial functional guilds performing cryptic organotrophic and lithotrophic redox cycles in anaerobic granular biofilms.PloS one · 2025Article
- Gene-centered metagenome analysis of Vulcano Island soil (Aeolian archipelago, Italy) reveals diverse microbial key players in methane, hydrogen and sulfur cycles.Antonie van Leeuwenhoek · 2024Article
- Substrate Specificity of Biofilms Proximate to Historic Shipwrecks.Microorganisms · 2023Article
- Volatile and Dissolved Organic Carbon Sources Have Distinct Effects on Microbial Activity, Nitrogen Content, and Bacterial Communities in Soil.Microbial ecology · 2023Article
- Anaerobic methane oxidation in a coastal oxygen minimum zone: spatial and temporal dynamics.Environmental microbiology · 2022Article
- Bioinorganic insights of the PQQ-dependent alcohol dehydrogenases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021Review
- Metagenomic Insight into Environmentally Challenged Methane-Fed Microbial Communities.Microorganisms · 2020Article
- Evolution in action: habitat transition from sediment to the pelagial leads to genome streamlining in Methylophilaceae.The ISME journal · 2019Article
- Article
- Members of the GenusmBio · 2018Article
- Facile Arsenazo III-Based Assay for Monitoring Rare Earth Element Depletion from Cultivation Media for Methanotrophic and Methylotrophic Bacteria.Applied and environmental microbiology · 2018Article
- Similar but Not the Same: First Kinetic and Structural Analyses of a Methanol Dehydrogenase Containing a Europium Ion in the Active Site.Chembiochem : a European journal of chemical biology · 2018Article
- Lanthanide-Dependent Methanol Dehydrogenases of XoxF4 and XoxF5 Clades Are Differentially Distributed Among Methylotrophic Bacteria and They Reveal Different Biochemical Properties.Frontiers in microbiology · 2018Article
- Communal metabolism of methane and the rare Earth element switch.Journal of bacteriology · 2017Article
- Lanthanide-dependent cross-feeding of methane-derived carbon is linked by microbial community interactions.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Methylophilaceae and Hyphomicrobium as target taxonomic groups in monitoring the function of methanol-fed denitrification biofilters in municipal wastewater treatment plants.Journal of industrial microbiology & biotechnology · 2017Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe five novel Methylophilaceae ecotypes from a single ecological niche in Lake Washington, USA, and compare them to three previously described ecotypes, in terms of their phenotype and genome sequence divergence. Two of the ecotypes appear to represent novel genera within the Methylophilaceae. Genome-based metabolic reconstruction highlights metabolic versatility of Methylophilaceae with respect to methylotrophy and nitrogen metabolism, different ecotypes possessing different combinations of primary substrate oxidation systems (MxaFI-type methanol dehydrogenase versus XoxF-type methanol dehydrogenase; methylamine dehydrogenase versus N-methylglutamate pathway) and different potentials for denitrification (assimilatory versus respiratory nitrate reduction). By comparing pairs of closely related genomes, we uncover that site-specific recombination is the main means of genomic evolution and strain divergence, including lateral transfers of genes from both closely- and distantly related taxa. The new ecotypes and the new genomes contribute significantly to our understanding of the extent of genomic and metabolic diversity among organisms of the same family inhabiting the same ecological niche. These organisms also provide novel experimental models for studying the complexity and the function of the microbial communities active in methylotrophy.
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Registered trials
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