SynthesisPLoS neglected tropical diseases2014
Risk factors for adverse prognosis and death in American visceral leishmaniasis: a meta-analysis.
Synthesis in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- An updated systematic review with meta-analysis and meta-regression of the factors associated with human visceral leishmaniasis in the Americas.Infectious diseases of poverty · 2025Pooled it
- Prognostic factors for mortality among patients with visceral leishmaniasis in East Africa: Systematic review and meta-analysis.PLoS neglected tropical diseases · 2020Pooled it
- Efficacy and safety of available treatments for visceral leishmaniasis in Brazil: A multicenter, randomized, open label trial.PLoS neglected tropical diseases · 2017Trial
- Systemic inflammatory markers of visceral leishmaniasis treatment response in East Africa.PLoS neglected tropical diseases · 2026Article
- Epidemiological Shifts in Visceral Leishmaniasis Incidence, Relapse, and Mortality in Brazil, 2007-2023: Analysis Using the National Notifiable Diseases Information System.Open forum infectious diseases · 2026Article
- Global, regional, and national age-gender-specific trends, decomposition analysis, and Bayesian age-period-cohort modelling for projections of the burden of leishmaniasis: A population-based ecological study.Current research in parasitology & vector-borne diseases · 2026Article
- Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review.BMJ public health · 2026Article
- Phenotypic characterization of mucosal-associated invariant T cells in visceral leishmaniasis and HIV co-infection.Frontiers in immunology · 2026Article
- Evaluating the contribution of weather variables to machine learning forecasts of visceral leishmaniasis in Brazil.Environmental research, health : ERH · 2025Article
- Relationship of the Landscape Configuration with the Gut Parasites and Fungi Diversity in Farm Animals Associated with Conservation Areas in Colombia: Epidemiological Risk to Wildlife.Acta parasitologica · 2025Article
- Interleukin-8 Predicts Fatal Kala-Azar: A Case-Control Study.Tropical medicine and infectious disease · 2025Article
- AI-driven analysis by identifying risk factors of VL relapse in HIV co-infected patients.Scientific reports · 2025Article
- Human Visceral Leishmaniasis in Brazil in the Past 20 Years: An Epidemiologic Update.Revista da Sociedade Brasileira de Medicina Tropical · 2025Review
- Time to recovery from visceral leishmaniasis and its predictors of mature visceral leishmaniasis patients admitted at Metema Hospital, Metema, Ethiopia.Scientific reports · 2024Article
- Association between clinical outcomes, peripheral blood and cytomorphologic features of bone marrow in visceral leishmaniasis.Hematology, transfusion and cell therapy · 2024Article
- An update onParasite epidemiology and control · 2024Review
- Prognostic prediction models for clinical outcomes in patients diagnosed with visceral leishmaniasis: protocol for a systematic review.BMJ open · 2023Article
- Article
- From Infection to Death: An Overview of the Pathogenesis of Visceral Leishmaniasis.Pathogens (Basel, Switzerland) · 2023Review
- The Influence of Community Feeders and Commercial Food Outlets on the Spatial Distribution of Free-Roaming Dogs-A Photographic Capture and Recapture Study.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the current context of high fatality rates associated with American visceral leishmaniasis (VL), the appropriate use of prognostic factors to identify patients at higher risk of unfavorable outcomes represents a potential tool for clinical practice. This systematic review brings together information reported in studies conducted in Latin America, on the potential predictors of adverse prognosis (continued evolution of the initial clinical conditions of the patient despite the implementation of treatment, independent of the occurrence of death) and death from VL. The limitations of the existing knowledge, the advances achieved and the approaches to be used in future research are presented. METHODS/PRINCIPAL
findingsThe full texts of 14 studies conforming to the inclusion criteria were analyzed and their methodological quality examined by means of a tool developed in the light of current research tools. Information regarding prognostic variables was synthesized using meta-analysis. Variables were grouped according to the strength of evidence considering summary measures, patterns and heterogeneity of effect-sizes, and the results of multivariate analyses. The strongest predictors identified in this review were jaundice, thrombocytopenia, hemorrhage, HIV coinfection, diarrhea, age <5 and age >40-50 years, severe neutropenia, dyspnoea and bacterial infections. Edema and low hemoglobin concentration were also associated with unfavorable outcomes. The main limitation identified was the absence of validation procedures for the few prognostic models developed so far. CONCLUSIONS/SIGNIFICANCE: Integration of the results from different investigations conducted over the last 10 years enabled the identification of consistent prognostic variables that could be useful in recognizing and handling VL patients at higher risk of unfavorable outcomes. The development of externally validated prognostic models must be prioritized in future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.