ArticlePLoS neglected tropical diseases2014
The incidence of Japanese encephalitis in Taiwan--a population-based study.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Estimates of Japanese Encephalitis mortality and morbidity: A systematic review and modeling analysis.PLoS neglected tropical diseases · 2022Pooled it
- Seroprevalence of Japanese Encephalitis Virus, and Immunogenicity of the Vero-Cell Culture-Derived Vaccine in Hematopoietic Stem Cell Transplantation Recipients.Journal of Korean medical science · 2026Article
- Epidemiological Features, Clinical Symptoms, and Environmental Risk Factors for Notifiable Japanese Encephalitis in Taiwan From 2008 to 2020: Retrospective Study.JMIR public health and surveillance · 2025Article
- Impact of vaccination against Japanese encephalitis in endemic countries.PLoS neglected tropical diseases · 2024Article
- Antibodies from dengue patients with prior exposure to Japanese encephalitis virus are broadly neutralizing against Zika virus.Communications biology · 2024Article
- Epidemiology and risk factors of Japanese encephalitis in Taiwan, 2010-2022.PLoS neglected tropical diseases · 2023Article
- A Serosurvey of Japanese Encephalitis Virus in Monkeys and Humans Living in Proximity in Thailand.Viruses · 2023Article
- Japanese Encephalitis among Adults: A Review.The American journal of tropical medicine and hygiene · 2023Review
- Who Is at Risk? A Critical Case of Japanese Encephalitis.Journal of acute medicine · 2022Article
- Seroepidemiological study of Japanese encephalitis virus in Chiang Mai: Immunity and susceptibility 28 years after introduction of a vaccination programme.PLoS neglected tropical diseases · 2022Article
- The epidemiology and disease burden of children hospitalized for viral infections within the family Flaviviridae in China: A national cross-sectional study.PLoS neglected tropical diseases · 2022Article
- Importance of maintaining a high childhood vaccination rate and surveillance program against Japanese encephalitis in Korea.Clinical and experimental pediatrics · 2022Article
- Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea.Clinical and experimental pediatrics · 2022Article
- Seroepidemiological Studies on Japanese Encephalitis: A Systematic Review.Oman medical journal · 2022Review
- Safety of Japanese encephalitis vaccines.Human vaccines & immunotherapeutics · 2021Article
- Long-term neurological and healthcare burden of adults with Japanese encephalitis: A nationwide study 2000-2015.PLoS neglected tropical diseases · 2021Article
- Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China.Annals of global health · 2021Article
- Serological and molecular epidemiology of Japanese Encephalitis in Zhejiang, China, 2015-2018.PLoS neglected tropical diseases · 2020Article
- Article
- Decreases in Both the Seroprevalence of Serum Antibodies and Seroprotection against Japanese Encephalitis Virus among Vaccinated Children.Virologica Sinica · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA mass Japanese encephalitis (JE) vaccination program targeting children was launched in Taiwan in 1968, and the number of pediatric JE cases substantially decreased thereafter. The aim of this study was to elucidate the long-term trend of JE incidence, and to investigate the age-specific seroprevalence of JE-neutralizing antibodies. METHODOLOGY/PRINCIPAL
findingsA total of 2,948 laboratory-confirmed JE cases that occurred between 1966 and 2012 were analyzed using a mandatory notification system managed by the Centers for Disease Control, Taiwan. A total of 6,594 randomly-sampled serum specimens obtained in a nationwide population-based survey in 2002 were analyzed to estimate the seroprevalence of JE-neutralizing antibodies in the general population. The average annual JE incidence rate of the group aged 30 years and older was 0.167 cases per 100,000 people between 2001 and 2012, which was higher than the 0.052 cases per 100,000 people among those aged under 30 years. These seroepidemiological findings indicate that the cohort born between 1963 and 1975, who generally received two or three doses of the vaccine and were administered the last booster dose more than 20 years ago, exhibited the lowest positive rate of JE-neutralizing antibodies (54%). The highest and second highest antibody rates were observed, respectively, in the oldest unvaccinated cohort (86%) and in the youngest cohort born between 1981 and 1986, who received four doses 10-15 years ago (74%). CONCLUSION/SIGNIFICANCE: Over the past decade, the main age group of the confirmed JE cases in Taiwan shifted from young children to adults over 30 years of age. People who were born between 1963 and 1975 exhibited the lowest seroprevalence of JE-neutralizing antibodies. Thus, the key issue for JE control in Taiwan is to reduce adult JE cases through a cost-effective analysis of various immunization strategies.
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