Evidence map›Paper›PMID 2505749›Full record

ArticleThe Biochemical journal1989

Glucocorticoids modulate mRNA levels for G-protein beta-subunits.

M Ros, D C Watkins, P J Rapiejko, C C Malbon

Open access · bronzeAbstract read
In one paragraph

Article in The Biochemical journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 34 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M RosDepartment of Pharmacological Sciences, School of Medicine, State University of New York, Stony Brook 11794-8651.
D C Watkins
P J Rapiejko
C C Malbon
Stony Brook University · US

Funding

STRUCTURE AND BIOLOGY OF BETA-ADRENERGIC RECEPTORSR01DK025410 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI MALBON, CRAIG C · 1986 to 2011
$5.0M
REGULATION OF HORMONE-SENSITIVE EFFECTOR SYSTEMSR01DK030111 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI MALBON, CRAIG C · 1986 to 2010
$3.5M
NIDDK NIH HHS DK25410NIDDK NIH HHS DK30111
6 · The paper itself

Abstract

Adrenalectomy decreases, whereas glucocorticoid treatment increases, the steady-state levels of G-protein beta-subunits (G beta) in rat fat-cells. A DNA-excess solution-hybridization assay was established to define the steady-state mRNA levels for G beta [5.8 +/- 0.4 amol/micrograms of RNA (n = 5) in control fat-cells]. G beta mRNA levels decrease by 20% after adrenalectomy; dexamethasone treatment reverses the decline. Dexamethasone treatment itself increases G beta mRNA levels by 50%.

Indexed as

GTP-Binding ProteinsAdipose TissueAnimalsDexamethasoneRatsRNA, MessengerDexamethasoneGTP-Binding ProteinsRNA, Messenger

Identifiers

PMID2505749
PMCPMC1138656
OpenAlexW2409588259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.