ArticleNeuroImage. Clinical2014
A tensor-based morphometry analysis of regional differences in brain volume in relation to prenatal alcohol exposure.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Recent breakthroughs in understanding the cerebellum's role in fetal alcohol spectrum disorder: A systematic review.Alcohol (Fayetteville, N.Y.) · 2024Pooled it
- Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes.Alcoholism, clinical and experimental research · 2021Trial
- Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders.Scientific reports · 2021Trial
- Feasibility and Acceptability of Maternal Choline Supplementation in Heavy Drinking Pregnant Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Alcoholism, clinical and experimental research · 2018Trial
- FASD Science and Policy Depend on Deeply Phenotyped Prospective Birth Cohorts.Alcohol, clinical & experimental research · 2026Article
- Anatomy-aware, label-informed approach improves image registration for challenging datasets.PloS one · 2026Article
- Impact of Developmental Alcohol Exposure on the Thalamus.Advances in experimental medicine and biology · 2025Review
- Article
- Longitudinal Relationship Between Brain Atrophy Patterns, Cognitive Decline, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease Explored by Orthonormal Projective Non-Negative Matrix Factorization.Journal of Alzheimer's disease : JAD · 2024Article
- Binge-like ethanol exposure during the brain growth spurt disrupts the function of retrosplenial cortex-projecting anterior thalamic neurons in adolescent mice.Neuropharmacology · 2023Article
- Stability and change in the interpretation of facial emotions in fetal alcohol spectrum disorders from childhood to adolescence.Alcoholism, clinical and experimental research · 2022Article
- Reading impairment in adolescents with fetal alcohol spectrum disorders.Scientific studies of reading : the official journal of the Society for the Scientific Study of Reading · 2022Article
- Pilot Study on Analysis of Electroencephalography Signals from Children with FASD with the Implementation of Naive Bayesian Classifiers.Sensors (Basel, Switzerland) · 2021Article
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- Effects of Prenatal Alcohol Exposure on the Volumes of the Lateral and Medial Walls of the Intraparietal Sulcus.Frontiers in neuroanatomy · 2021Article
- Reduced fractional anisotropy in projection, association, and commissural fiber networks in neonates with prenatal methamphetamine exposure.Developmental neurobiology · 2020Article
- Graded Cerebellar Lobular Volume Deficits in Adolescents and Young Adults with Fetal Alcohol Spectrum Disorders (FASD).Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence.JAMA psychiatry · 2020Article
- Reduced Hippocampal Volumes Partially Mediate Effects of Prenatal Alcohol Exposure on Spatial Navigation on a Virtual Water Maze Task in Children.Alcoholism, clinical and experimental research · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Reductions in brain volumes represent a neurobiological signature of fetal alcohol spectrum disorders (FASD). Less clear is how regional brain tissue reductions differ after normalizing for brain size differences linked with FASD and whether these profiles can predict the degree of prenatal exposure to alcohol. To examine associations of regional brain tissue excesses/deficits with degree of prenatal alcohol exposure and diagnosis with and without correction for overall brain volume, tensor-based morphometry (TBM) methods were applied to structural imaging data from a well-characterized, demographically homogeneous sample of children diagnosed with FASD (n = 39, 9.6-11.0 years) and controls (n = 16, 9.5-11.0 years). Degree of prenatal alcohol exposure was significantly associated with regionally pervasive brain tissue reductions in: (1) the thalamus, midbrain, and ventromedial frontal lobe, (2) the superior cerebellum and inferior occipital lobe, (3) the dorsolateral frontal cortex, and (4) the precuneus and superior parietal lobule. When overall brain size was factored out of the analysis on a subject-by-subject basis, no regions showed significant associations with alcohol exposure. FASD diagnosis was associated with a similar deformation pattern, but few of the regions survived FDR correction. In data-driven independent component analyses (ICA) regional brain tissue deformations successfully distinguished individuals based on extent of prenatal alcohol exposure and to a lesser degree, diagnosis. The greater sensitivity of the continuous measure of alcohol exposure compared with the categorical diagnosis across diverse brain regions underscores the dose dependence of these effects. The ICA results illustrate that profiles of brain tissue alterations may be a useful indicator of prenatal alcohol exposure when reliable historical data are not available and facial features are not apparent.
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