ArticleNeuroImage. Clinical2014
Aberrant error processing in relation to symptom severity in obsessive-compulsive disorder: A multimodal neuroimaging study.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- Electrophysiological Correlates of Cognitive Dysfunction in Obsessive-Compulsive Disorder (OCD): A Systematic and Mechanistic Review of EEG, ERP, and QEEG Evidence.Journal of clinical medicine · 2026Review
- Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder.Depression and anxiety · 2026Article
- Evidence of neurocognitive and resting state functional connectivity differences in carriers of NRXN1 deletions.Journal of neurodevelopmental disorders · 2025Article
- Threats That Arise From Within: Changes in Error Processing and the Prospective Prediction of Everyday Avoidance.Biological psychiatry global open science · 2025Article
- Error-related brain activity associated with obsessive-compulsive symptoms in youth.Brain and behavior · 2023Article
- Maladaptive self-focused attention and default mode network connectivity: a transdiagnostic investigation across social anxiety and body dysmorphic disorders.Social cognitive and affective neuroscience · 2022Article
- Post-error slowing in anxiety and obsessive-compulsive disorders.Cognitive, affective & behavioral neuroscience · 2022Article
- How to measure post-error slowing: The case of pre-error speeding.Behavior research methods · 2022Article
- Specific Aspects of Eye Movement Reactions as Markers of Cognitive Control Disorders in Patients with Obsessive-Compulsive Disorder (Review).Sovremennye tekhnologii v meditsine · 2022Review
- The prefrontal cortex and OCD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Neurocognitive Endophenotypes of OCD.Current topics in behavioral neurosciences · 2021Article
- Exploring response inhibition and error monitoring in obsessive-compulsive disorder.Journal of psychiatric research · 2020Article
- Intolerance of uncertainty, depression and the error-related negativity.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
- Optimizing assessments of post-error slowing: A neurobehavioral investigation of a flanker task.Psychophysiology · 2020Article
- Development of Posterior Medial Frontal Cortex Function in Pediatric Obsessive-Compulsive Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Support Vector Machine Classification of Obsessive-Compulsive Disorder Based on Whole-Brain Volumetry and Diffusion Tensor Imaging.Frontiers in psychiatry · 2018Article
- Impaired Antisaccades in Obsessive-Compulsive Disorder: Evidence From Meta-Analysis and a Large Empirical Study.Frontiers in psychiatry · 2018Article
- Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves.eLife · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundObsessive-compulsive disorder (OCD) is characterized by maladaptive repetitive behaviors that persist despite feedback. Using multimodal neuroimaging, we tested the hypothesis that this behavioral rigidity reflects impaired use of behavioral outcomes (here, errors) to adaptively adjust responses. We measured both neural responses to errors and adjustments in the subsequent trial to determine whether abnormalities correlate with symptom severity. Since error processing depends on communication between the anterior and the posterior cingulate cortex, we also examined the integrity of the cingulum bundle with diffusion tensor imaging.
methodsParticipants performed the same antisaccade task during functional MRI and electroencephalography sessions. We measured error-related activation of the anterior cingulate cortex (ACC) and the error-related negativity (ERN). We also examined post-error adjustments, indexed by changes in activation of the default network in trials surrounding errors.
resultsOCD patients showed intact error-related ACC activation and ERN, but abnormal adjustments in the post- vs. pre-error trial. Relative to controls, who responded to errors by deactivating the default network, OCD patients showed increased default network activation including in the rostral ACC (rACC). Greater rACC activation in the post-error trial correlated with more severe compulsions. Patients also showed increased fractional anisotropy (FA) in the white matter underlying rACC.
conclusionsImpaired use of behavioral outcomes to adaptively adjust neural responses may contribute to symptoms in OCD. The rACC locus of abnormal adjustment and relations with symptoms suggests difficulty suppressing emotional responses to aversive, unexpected events (e.g., errors). Increased structural connectivity of this paralimbic default network region may contribute to this impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.