ArticleNeuroImage. Clinical2014
Anatomical and diffusion MRI of deep gray matter in pediatric spina bifida.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Are Shunt Revisions Associated with IQ in Congenital Hydrocephalus? A Meta -Analysis.Neuropsychology review · 2016Pooled it
- Subcortical morphological alterations and volume loss in infantile hydrocephalus: A surface- and volume-based analysis.Neuroimage. Reports · 2026Article
- Long-term cognitive outcomes of Chiari II malformation and corpus callosum abnormalities in myelomeningocele.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Variation in Neurodegeneration-Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida.Annals of the Child Neurology Society · 2025Article
- Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Brain abnormalities in myelomeningocele patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Abnormal anisotropic diffusion properties in pediatric myelomeningocele patients treated with fetal surgery: an initial DTI study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Validation of the Fetal Lamb Model of Spina Bifida.Scientific reports · 2019Article
- Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele.Neuropsychology · 2017Article
- Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes.Journal of neurosurgery. Pediatrics · 2016Article
- Gray matter integrity within regions of the dorsolateral prefrontal cortical-subcortical network predicts executive function and fine motor dexterity in spina bifida.Neuropsychology · 2016Article
- Spina bifida.Nature reviews. Disease primers · 2015Review
- Prospective and episodic memory in relation to hippocampal volume in adults with spina bifida myelomeningocele.Neuropsychology · 2015Article
- Analysis of Denver Neurodevelopmental Screening Test Results of Myelomeningocele, Hydrocephalus, and Microcephaly Patients.Journal of pediatric neurosciencesArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Individuals with spina bifida myelomeningocele (SBM) exhibit brain abnormalities in cortical thickness, white matter integrity, and cerebellar structure. Little is known about deep gray matter macro- and microstructure in this population. The current study utilized volumetric and diffusion-weighted MRI techniques to examine gray matter volume and microstructure in several subcortical structures: basal ganglia nuclei, thalamus, hippocampus, and amygdala. Sixty-six children and adolescents (ages 8-18; M = 12.0, SD = 2.73) with SBM and typically developing (TD) controls underwent T1- and diffusion-weighted neuroimaging. Microstructural results indicated that hippocampal volume was disproportionately reduced, whereas the putamen volume was enlarged in the group with SBM. Microstructural analyses indicated increased mean diffusivity (MD) and fractional anisotropy (FA) in the gray matter of most examined structures (i.e., thalamus, caudate, hippocampus), with the putamen exhibiting a unique pattern of decreased MD and increased FA. These results provide further support that SBM differentially disrupts brain regions whereby some structures are volumetrically normal whereas others are reduced or enlarged. In the hippocampus, volumetric reduction coupled with increased MD may imply reduced cellular density and aberrant organization. Alternatively, the enlarged volume and significantly reduced MD in the putamen suggest increased density.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.