Evidence map›Paper›PMID 25057429›Full record

ArticleJournal of cancer therapy2013

Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma.

Ka-To Shum, Jiehua Zhou, John J Rossi

Open access · diamondAbstract read
In one paragraph

Article in Journal of cancer therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Therapeutic Potential of Aptamer-Protein Interactions.ACS pharmacology & translational science · 2022
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Therapeutic nucleic acids: current clinical status.British journal of clinical pharmacology · 2016
    Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ka-To ShumDepartment of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Jiehua ZhouDepartment of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA.
John J RossiDepartment of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA ; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Beckman Research InstituteCity of Hope · US

Funding

COMBINATORIAL USE OF CCR5 RIBOZYMES WITH ANTI HIV1 RNASR01AI042552 · NIAID · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI ROSSI, JOHN JOSEPH · 1998 to 2019
$7.8M
YEAST SYSTEM FOR DEVELOPING ANTI-HIV-1 RIBOZYMESR01AI029329 · NIAID · LOMA LINDA UNIVERSITY · PI ROSSI, JOHN JOSEPH · 1990 to 2018
$3.9M
RNA Nanotechnology in Cancer TherapyU01CA151648 · NCI · UNIVERSITY OF KENTUCKY · PI GUO, PEIXUAN, LI, HENRY · 2010 to 2014
$2.1M
NCI NIH HHS U01 CA151648NIAID NIH HHS R01 AI029329NIAID NIH HHS R01 AI042552
6 · The paper itself

Abstract

Lymphomas are cancers that arise from white blood cells and usually present as solid tumors. Treatment of lymphoma often involves chemotherapy, and can also include radiotherapy and/or bone marrow transplantation. There is an un-questioned need for more effective therapies and diagnostic tool for lymphoma. Aptamers are single stranded DNA or RNA oligonucleotides whose three-dimensional structures are dictated by their sequences. The immense diversity in function and structure of nucleic acids enable numerous aptamers to be generated through an iterative

Indexed as

BiosensorCell-Type Specific Drug DeliveryLymphomaNanotechnologyNucleic Acid AptamerSELEX

Identifiers

PMID25057429
PMCPMC4104705
OpenAlexW2019767543

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.