Evidence map›Paper›PMID 25057406›Full record

ArticleJRSM open2014

Early life factors in relation to cardiovascular risk and cardiovascular disease in old age in Bergen: a Norwegian retrospective cohort study based on the Hordaland Health Study (HUSK).

Jens Christoffer Skogen, Robert Stewart, Marit Knapstad, Simon Overland, Arnstein Mykletun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JRSM open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Jens Christoffer SkogenDepartment of Health Promotion and Development, Faculty of Psychology, University of Bergen, Bergen 5020, Norway ; Alcohol and Drug Research Western Norway, Stavanger University Hospital, Stavanger 4010, Norway ; Department of Public Mental Health, Division of Mental Health, Norwegian Institute of Public Health, Bergen 5018, Norway.
Robert StewartInstitute of Psychiatry, King's College London, London WC2R 2LS, UK.
Marit KnapstadDepartment of Health Promotion and Development, Faculty of Psychology, University of Bergen, Bergen 5020, Norway ; Department of Public Mental Health, Division of Mental Health, Norwegian Institute of Public Health, Bergen 5018, Norway.
Simon OverlandDepartment of Health Promotion and Development, Faculty of Psychology, University of Bergen, Bergen 5020, Norway ; Department of Public Mental Health, Division of Mental Health, Norwegian Institute of Public Health, Bergen 5018, Norway.
Arnstein MykletunDepartment of Public Mental Health, Division of Mental Health, Norwegian Institute of Public Health, Bergen 5018, Norway ; School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia.
Norwegian Institute of Public Health · NOKing's College London · GBUniversity of Bergen · NOUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe fetal origins of adult disease hypothesis describes associations found for fetal or early-life exposures with cardiovascular risk and disease in adulthood. The extension or not of these associations into old age has received less attention. We investigated if maternal health and family circumstances were associated with cardiovascular risk factors and cardiovascular disease (CVD) in late life and discuss results in light of possible selection effects and measurement error.

designA retrospective cohort study based on community survey. We examined 224 possible associations between anthropometric measures, maternal health information and family socioeconomic status at birth versus CVD and CVD-related risk factors 72-74 years later.

participantsOf 3341 participants in a community survey of people aged 72-74 years, we were able to trace birth records from a historical archive in a broadly representative subsample of 480.

settingBergen, Norway.

main outcome measuresEstablished cardiovascular risk factors and indicators of CVD.

resultsOnly 11 (4.9%) of these associations were found to be statistically significant, and no strong or consistent patterns in the associations between exposures and outcomes were found.

conclusionsThere was little evidence in this relatively elderly sample for an association between early life factors and CVD outcomes of clinical or public health relevance. Further research is required to confirm the extent to which a diminution of early life influences into old age, if genuine, can be accounted for by selective mortality, systematic bias or by dilution of effects due to competing risk factors.

Indexed as

birthweightcardiovascular diseaseearly life factorsfetal origins of adult diseaseold agepublic health

Identifiers

PMID25057406
PMCPMC4100231
OpenAlexW2053133509

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.