Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Random positions of dendritic spines in human cerebral cortex.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Enhanced Distal Signaling in Human Hippocampal Neurons despite Lower Intrinsic Excitability.Research square · 2025Article
- The effects of axonal beading and undulation on axonal diameter estimation from diffusion MRI: Insights from simulations in human axons segmented from three-dimensional electron microscopy.NMR in biomedicine · 2024Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- The Subcortical-Allocortical- NeocorticalFrontiers in synaptic neuroscience · 2021Article
- In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter.NeuroImage · 2020Article
- Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type.Nature neuroscience · 2018Article
- Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- The human medial amygdala: structure, diversity, and complexity of dendritic spines.Journal of anatomy · 2015Article
- Quantifying the Number of Discriminable Coincident Dendritic Input Patterns through Dendritic Tree Morphology.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Dendritic spines establish most excitatory synapses in the brain and are located in Purkinje cell's dendrites along helical paths, perhaps maximizing the probability to contact different axons. To test whether spine helixes also occur in neocortex, we reconstructed >500 dendritic segments from adult human cortex obtained from autopsies. With Fourier analysis and spatial statistics, we analyzed spine position along apical and basal dendrites of layer 3 pyramidal neurons from frontal, temporal, and cingulate cortex. Although we occasionally detected helical positioning, for the great majority of dendrites we could not reject the null hypothesis of spatial randomness in spine locations, either in apical or basal dendrites, in neurons of different cortical areas or among spines of different volumes and lengths. We conclude that in adult human neocortex spine positions are mostly random. We discuss the relevance of these results for spine formation and plasticity and their functional impact for cortical circuits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.