ArticleJournal of neurophysiology2014
Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03687892 (Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pharmacological adjuncts and transcranial magnetic stimulation-induced synaptic plasticity: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- The effects of D-Cycloserine on corticospinal excitability after repeated spaced intermittent theta-burst transcranial magnetic stimulation: A randomized controlled trial in healthy individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Theta oscillations tag episodic memories for sleep-dependent consolidation.PLoS biology · 2026Article
- The how and why for multiple forms of hippocampal LTP.Frontiers in synaptic neuroscience · 2026Review
- Optimizing Treatment: Case Series of a Time-Efficient Accelerated Intermittent Theta Burst Stimulation Protocol for Depression and Call for a Protocol Consensus in Clinical Trials.Psychiatry investigation · 2026Article
- Review
- A synapse-specific refractory period for plasticity at individual dendritic spines.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Contributions of site- and sex-specific LTPs to everyday memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- A synapse-specific refractory period for plasticity at individual dendritic spines.bioRxiv : the preprint server for biology · 2024Article
- Pre- versus Post-synaptic Forms of LTP in Two Branches of the Same Hippocampal Afferent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Improving efficacy of repetitive transcranial magnetic stimulation for treatment of Parkinson disease gait disorders.Frontiers in human neuroscience · 2024Article
- Global research hotspots and trends of theta burst stimulation from 2004 to 2023: a bibliometric analysis.Frontiers in neurology · 2024Article
- Sex differences in synaptic plasticity underlying learning.Journal of neuroscience research · 2023Review
- Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats.Frontiers in neurology · 2023Article
- Article
- Making a Lecture Stick: the Effect of Spaced Instruction on Knowledge Retention in Medical Education.Medical science educator · 2020Article
- Synaptic Odyssey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- How to Design Optimal Accelerated rTMS Protocols Capable of Promoting Therapeutically Beneficial Metaplasticity.Frontiers in neurology · 2020Article
- Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampal long-term potentiation (LTP) is a model system for studying cellular mechanisms of learning and memory. Recent interest in mechanisms underlying the advantage of spaced over massed learning has prompted investigation into the effects of distributed episodes of LTP induction. The amount of LTP induced in hippocampal area CA1 by one train (1T) of theta-burst stimulation (TBS) in young Sprague-Dawley rats was further enhanced by additional bouts of 1T given at 1-h intervals. However, in young Long-Evans (LE) rats, 1T did not initially saturate LTP. Instead, a stronger LTP induction paradigm using eight trains of TBS (8T) induced saturated LTP in hippocampal slices from both young and adult LE rats as well as adult mice. The saturated LTP induced by 8T could be augmented by another episode of 8T following an interval of at least 90 min. The success rate across animals and slices in augmenting LTP by an additional episode of 8T increased significantly with longer intervals between the first and last episodes, ranging from 0% at 30- and 60-min intervals to 13-66% at 90- to 180-min intervals to 90-100% at 240-min intervals. Augmentation above initially saturated LTP was blocked by the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV). These findings suggest that the strength of induction and interval between episodes of TBS, as well as the strain and age of the animal, are important components in the augmentation of LTP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.