Evidence map›Paper›PMID 25057044›Full record

ArticleThe Journal of infectious diseases2015

Too late to vaccinate? The incremental benefits and cost-effectiveness of a delayed catch-up program using the 4-valent human papillomavirus vaccine in Norway.

Emily A Burger, Stephen Sy, Mari Nygård, Ivar S Kristiansen, Jane J Kim

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  9. Surveillance of Vaccination Coverage among Adult Populations - United States, 2015.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2017
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emily A BurgerDepartment of Health Management and Health Economics, University of Oslo Center for Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts.
Stephen SyCenter for Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts.
Mari NygårdCancer Registry of Norway, Department of Research, Oslo.
Ivar S KristiansenDepartment of Health Management and Health Economics, University of Oslo.
Jane J KimCenter for Health Decision Science, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts.
Cancer Registry of Norway · NOUniversity of Oslo · NO

Funding

Comparative and Cost-Effectiveness of Preventing HPV-Related DiseasesR01CA160744 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI KIM, JANE JOOYUN · 2012 to 2015
$1.2M
NCI NIH HHS R01 CA160744NCI NIH HHS R01CA160744
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) vaccines are ideally administered before HPV exposure; therefore, catch-up programs for girls past adolescence have not been readily funded. We evaluated the benefits and cost-effectiveness of a delayed, 1-year female catch-up vaccination program in Norway.

methodsWe calibrated a dynamic HPV transmission model to Norwegian data and projected the costs and benefits associated with 8 HPV-related conditions while varying the upper vaccination age limit to 20, 22, 24, or 26 years. We explored the impact of vaccine protection in women with prior vaccine-targeted HPV infections, vaccine cost, coverage, and natural- and vaccine-induced immunity.

resultsThe incremental benefits and cost-effectiveness decreased as the upper age limit for catch-up increased. Assuming a vaccine cost of $150/dose, vaccination up to age 20 years remained below Norway's willingness-to-pay threshold (approximately $83 000/quality-adjusted life year gained); extension to age 22 years was cost-effective at a lower cost per dose ($50-$75). At high levels of vaccine protection in women with prior HPV exposure, vaccinating up to age 26 years was cost-effective. Results were stable with lower coverage.

conclusionsHPV vaccination catch-up programs, 5 years after routine implementation, may be warranted; however, even at low vaccine cost per dose, the cost-effectiveness of vaccinating beyond age 22 years remains uncertain.

Indexed as

AdolescentAdultChildCost-Benefit AnalysisFemaleHumansMaleNorwayPapillomavirus InfectionsPapillomavirus VaccinesYoung AdultPapillomavirus Vaccinescost-effectiveness analysisdisease transmission modelsherd immunityhuman papillomavirusvaccine

Identifiers

PMID25057044
PMCPMC4342693
OpenAlexW2128730433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.