ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- HnRNPK restrains memory precursor and plasma cell differentiation to control germinal center B-cell output.Cellular & molecular immunology · 2026Article
- BAFF and APRIL Receptors in B Cell Immunity and Autoimmunity.Immunological reviews · 2026Review
- RNA-binding proteins and ribonucleoproteins as determinants of immunity.Nature reviews. Immunology · 2026Review
- Article
- Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice.PLoS pathogens · 2024Article
- Systems genetics uncover new loci containing functional gene candidates inbioRxiv : the preprint server for biology · 2023Article
- IgD shapes the pre-immune naïve B cell compartment in humans.Frontiers in immunology · 2023Article
- Rad52 mediates class-switch DNA recombination to IgD.Nature communications · 2022Article
- Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.Nature communications · 2020Article
- Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.Nature immunology · 2019Article
- Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.The EMBO journal · 2019Article
- Ampk regulates IgD expression but not energy stress with B cell activation.Scientific reports · 2019Article
- The enigmatic function of IgD: some answers at last.European journal of immunology · 2018Review
- IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.eLife · 2018Article
- The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.Nature immunology · 2018Article
- RNA-binding proteins control gene expression and cell fate in the immune system.Nature immunology · 2018Review
- Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.Frontiers in immunology · 2018Review
- Splicing in immune cells-mechanistic insights and emerging topics.International immunology · 2017Review
- Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice.Development, growth & differentiation · 2016Article
- Recent advances in understanding transcription termination by RNA polymerase II.F1000Research · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The protein Zfp318 is expressed during the transition of naive B cells from an immature to mature state. To evaluate its role in mature B cell functions, a conditional gene deficiency in Zfp318 was created and deleted in bone marrow lineages via Vav-Cre. B cell development was minimally altered in the absence of the protein, although transitional 2 (T2) B cell populations were depressed in the absence of Zfp318. Intriguingly, the analysis of IgM and IgD expression by maturing and mature naive B cells demonstrated an elevated level of IgM gene products and a virtual loss of IgD products. Transcriptome analysis of Zfp318-deficient B cells revealed that only two gene products showed altered expression in the absence of Zfp318 (Ighd and Sva), demonstrating a remarkable specificity of Zfp318 action. In the absence of Zfp318, Ighm/Ighd transcripts, which would normally encode IgM and IgD from heterogeneous nuclear RNA transcripts via alternative splicing, lack intron and exon sequences from the IgD (Ighd)-encoding region. This finding indicates that Zfp318, in a novel manner, functions by repressing recognition of the transcriptional termination site at the 3' end of the terminal IgM-encoding exon, allowing for synthesis of the complete Ighm/Ighd heterogeneous nuclear RNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.