Evidence map›Paper›PMID 25057008›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2014

Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.

Yan Li, Zhidan Tu, Shiguang Qian, John J Fung, Sanford D Markowitz, Linda L Kusner, Henry J Kaminski, Lina Lu, Feng Lin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
  2. Tryptophan-immunoadsorption plasmapheresis regulates polymorphonuclear-myeloid-derived suppressor cells and pro-inflammatory cytokines.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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  5. Characterizing the Emergence of Myeloid-Derived Suppressor Cell Subsets in a Murine Model of Pulmonary Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yan LiDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195;
Zhidan TuDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106;
Shiguang QianDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195;
John J FungDepartment of Surgery, Cleveland Clinic, Cleveland, OH 44195;
Sanford D MarkowitzDepartment of Hematology and Oncology, Case Western Reserve University, Cleveland, OH 44106;
Linda L KusnerDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037; and.
Henry J KaminskiDepartment of Pharmacology and Physiology, George Washington University, Washington, DC 20037; and Department of Neurology, George Washington University, Washington, DC 20037.
Lina LuDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195;
Feng LinDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106; linf2@ccf.org.
Cleveland Clinic Lerner College of Medicine · USCase Western Reserve University · USGeorge Washington University · USCleveland Clinic · US

Funding

15-PGDH, A Novel in Vivo Suppressor of Colon Neoplasia in Mouse and ManR01CA127306 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2007 to 2011
$2.4M
Towards Induction of Cell Transplant ToleranceR01DK084192 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI LU, LINA · 2010 to 2014
$1.7M
Complement and OsteoporosisR01AR061564 · NIAMS · CLEVELAND CLINIC LERNER COM-CWRU · PI DENNIS, JAMES E, LIN, FENG C · 2012 to 2015
$1.5M
NCI NIH HHS CA127306NCI NIH HHS R01 CA127306NIAMS NIH HHS R01 AR061564NIDDK NIH HHS DK084192NIDDK NIH HHS R01 DK084192
6 · The paper itself

Abstract

We recently demonstrated that hepatic stellate cells induce the differentiation of myeloid-derived suppressor cells (MDSCs) from myeloid progenitors. In this study, we found that adoptive transfer of these MDSCs effectively reversed disease progression in experimental autoimmune myasthenia gravis (EAMG), a T cell-dependent and B cell-mediated model for myasthenia gravis. In addition to ameliorated disease severity, MDSC-treated EAMG mice showed suppressed acetylcholine receptor (AChR)-specific T cell responses, decreased levels of serum anti-AChR IgGs, and reduced complement activation at the neuromuscular junctions. Incubating MDSCs with B cells activated by anti-IgM or anti-CD40 Abs inhibited the proliferation of these in vitro-activated B cells. Administering MDSCs into mice immunized with a T cell-independent Ag inhibited the Ag-specific Ab production in vivo. MDSCs directly inhibit B cells through multiple mechanisms, including PGE2, inducible NO synthase, and arginase. Interestingly, MDSC treatment in EAMG mice does not appear to significantly inhibit their immune response to a nonrelevant Ag, OVA. These results demonstrated that hepatic stellate cell-induced MDSCs concurrently suppress both T and B cell autoimmunity, leading to effective treatment of established EAMG, and that the MDSCs inhibit AChR-specific immune responses at least partially in an Ag-specific manner. These data suggest that MDSCs could be further developed as a novel approach to treating myasthenia gravis and, even more broadly, other diseases in which T and B cells are involved in pathogenesis.

Indexed as

Myasthenia Gravis, Autoimmune, ExperimentalMyeloid CellsAnimalsAutoantibodiesB-LymphocytesDinoprostoneHepatic Stellate CellsImmunoglobulin GImmunoglobulin MMiceReceptors, NicotinicT-LymphocytesAutoantibodiesDinoprostoneImmunoglobulin GImmunoglobulin MReceptors, Nicotinic

Identifiers

PMID25057008
PMCPMC4784709
OpenAlexW1535157716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.