ArticleJournal of dental research2014
Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses.
Article in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Pooled it
- Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection.Clinical oral investigations · 2022Pooled it
- Identification of novel genome-wide pleiotropic associations with oral inflammatory traits.Molecular genetics and genomics : MGG · 2022Pooled it
- Genome-wide association study of periodontal pocketing in Finnish adults.BMC oral health · 2021Pooled it
- Pooled it
- Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.Scientific reports · 2018Pooled it
- Precision periodontology in clinical practice: bridging omics and clinical decision-making.Clinical oral investigations · 2026Review
- Review
- Periodontitis Continuum: Antecedents, Triggers, Mediators, and Treatment Strategies.Current medicinal chemistry · 2024Review
- The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications.Frontiers in immunology · 2024Review
- Identification of disease-associate variants of aggressive periodontitis using genome-wide association studies.The Japanese dental science review · 2023Review
- miRNAs from Inflamed Gingiva Link Gene Signaling to Increased MET Expression.Journal of dental research · 2023Article
- Associations between Host Genetic Variants and Subgingival Microbiota in Patients with the Metabolic Syndrome.International journal of molecular sciences · 2023Article
- Host Genotype Links to Salivary and Gut Microbiota by Periodontal Status.Journal of dental research · 2023Article
- DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues.Frontiers in oral health · 2023Article
- Article
- Codon Pattern and Compositional Constraints Determination of Genes Associated with Chronic Periodontitis.Genes · 2022Article
- Biome-microbiome interactions in peri-implantitis: A pilot investigation.Journal of periodontology · 2022Article
- Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health.Journal of clinical periodontology · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Recent genome-wide association studies (GWAS) of chronic periodontitis (CP) offer rich data sources for the investigation of candidate genes, functional elements, and pathways. We used GWAS data of CP (n = 4,504) and periodontal pathogen colonization (n = 1,020) from a cohort of adult Americans of European descent participating in the Atherosclerosis Risk in Communities study and employed a MAGENTA approach (i.e., meta-analysis gene set enrichment of variant associations) to obtain gene-centric and gene set association results corrected for gene size, number of single-nucleotide polymorphisms, and local linkage disequilibrium characteristics based on the human genome build 18 (National Center for Biotechnology Information build 36). We used the Gene Ontology, Ingenuity, KEGG, Panther, Reactome, and Biocarta databases for gene set enrichment analyses. Six genes showed evidence of statistically significant association: 4 with severe CP (NIN, p = 1.6 × 10(-7); ABHD12B, p = 3.6 × 10(-7); WHAMM, p = 1.7 × 10(-6); AP3B2, p = 2.2 × 10(-6)) and 2 with high periodontal pathogen colonization (red complex-KCNK1, p = 3.4 × 10(-7); Porphyromonas gingivalis-DAB2IP, p = 1.0 × 10(-6)). Top-ranked genes for moderate CP were HGD (p = 1.4 × 10(-5)), ZNF675 (p = 1.5 × 10(-5)), TNFRSF10C (p = 2.0 × 10(-5)), and EMR1 (p = 2.0 × 10(-5)). Loci containing NIN, EMR1, KCNK1, and DAB2IP had showed suggestive evidence of association in the earlier single-nucleotide polymorphism-based analyses, whereas WHAMM and AP2B2 emerged as novel candidates. The top gene sets included severe CP ("endoplasmic reticulum membrane," "cytochrome P450," "microsome," and "oxidation reduction") and moderate CP ("regulation of gene expression," "zinc ion binding," "BMP signaling pathway," and "ruffle"). Gene-centric analyses offer a promising avenue for efficient interrogation of large-scale GWAS data. These results highlight genes in previously identified loci and new candidate genes and pathways possibly associated with CP, which will need to be validated via replication and mechanistic studies.
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Registered trials
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