Evidence map›Paper›PMID 25056981›Full record

Trial reportBMJ open2014

RAndomised controlled trial to imProve depressIon and the quality of life of people with Dementia using cognitive bias modification: RAPID study protocol.

Osvaldo P Almeida, Colin MacLeod, Leon Flicker, Andrew Ford, Ben Grafton, Christopher Etherton-Beer

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Osvaldo P AlmeidaWestern Australian Centre for Heath & Ageing (M573), Centre for Medical Research of the Perkins Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia.
Colin MacLeodSchool of Psychology, University of Western Australia, Perth, Western Australia, Australia.
Leon FlickerWestern Australian Centre for Heath & Ageing (M573), Centre for Medical Research of the Perkins Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia Department of Geriatric Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.
Andrew FordWestern Australian Centre for Heath & Ageing (M573), Centre for Medical Research of the Perkins Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia Department of Psychiatry, Royal Perth Hospital, Perth, Western Australia, Australia.
Ben GraftonSchool of Psychology, University of Western Australia, Perth, Western Australia, Australia.
Christopher Etherton-BeerWestern Australian Centre for Heath & Ageing (M573), Centre for Medical Research of the Perkins Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia Department of Geriatric Medicine, Royal Perth Hospital, Perth, Western Australia, Australia.
University of Western Australia · AUHarry Perkins Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDepressive symptoms are common and undermine the quality of life of people with Alzheimer's disease (AD). Cholinesterase inhibitors and antidepressants have all but no effect on the mood of patients, and their use increases adverse events. Cognitive bias modification (CBM) targets attentional and interpretative biases associated with anxiety, dysphoria and depression and may be useful to treat depression in AD (DAD). This trial aims to determine the effect of CBM on depression scores and the quality of life of people with DAD. METHODS AND ANALYSIS: Randomised, double-blind, parallel, controlled trial of CBM (1:1 allocation ratio). Participants will be 80 adults with probable AD living in the Western Australian community who score 8 or more on the Cornell Scale for Depression in Dementia (CSDD). They will have mild to moderate dementia (Mini-Mental State Examination-MMSE score ≥15) and will be free of severe sensory impairment or suicidal intent. The intervention will consist of 10 40 min sessions of CBM delivered over 2 weeks using a high-resolution monitor using a local computer station at the Western Australian Centre for Health and Ageing. The primary outcomes of interest are the 2-week change, from baseline, in the severity of CSDD scores and the Quality of Life AD (QoL-AD) scores. Secondary outcomes include changes in the CSDD, QoL-AD after 12 weeks, and changes in MMSE scores, negative attentional and interpretative bias and the proportion of participants with CSDD <8 after 2 and 12 weeks. ETHICS AND DISSEMINATION: The study will comply with the principles of the Declaration of Helsinki and participants will provide written informed consent. The Ethics Committee of the Royal Perth Hospital will approve and oversee the study (REG14-036). The results of this trial will provide level 2 evidence of efficacy for CBM as a treatment of DAD. TRIAL REGISTRATION NUMBER: Australian and New Zealand Clinical Trials Registry number ACTRN12614000420640, date registered 06/04/2014.

Indexed as

Cognitive Behavioral TherapyQuality of LifeDementiaDepressionDouble-Blind MethodHumansResearch Design

Identifiers

PMID25056981
PMCPMC4120303
OpenAlexW2158977622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.