ArticleChemical senses2014
The regeneration of P2 olfactory sensory neurons is selectively impaired following methyl bromide lesion.
Article in Chemical senses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Article
- Integrated age-related immunohistological changes occur in human olfactory epithelium and olfactory bulb.The Journal of comparative neurology · 2022Article
- COVID-19 and olfactory dysfunction: a looming wave of dementia?Journal of neurophysiology · 2022Review
- Transient Effects of Cyclophosphamide on Basal Cell Proliferation of Olfactory Epithelia.Chemical senses · 2020Article
- The Phenomenon of Compensatory Cell Proliferation in Olfactory Epithelium in Fish Caused by Prolonged Exposure to Natural Odorants.Scientific reports · 2020Article
- [Progress in research on olfactory epithelial regeneration].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Review
- Cyclophosphamide has Long-Term Effects on Proliferation in Olfactory Epithelia.Chemical senses · 2020Article
- Matrix Metalloproteinase 9 and Osteopontin Interact to Support Synaptogenesis in the Olfactory Bulb after Mild Traumatic Brain Injury.Journal of neurotrauma · 2019Article
- Spatial Determination of Neuronal Diversification in the Olfactory Epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Neuroregenerative Capacity of Olfactory Stem Cells Is Not Limitless: Implications for Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Factors that modulate olfactory dysfunction.Neural regeneration research · 2018Review
- CanonicalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stem and progenitor cells of the mammalian olfactory epithelium: Taking poietic license.The Journal of comparative neurology · 2017Review
- Differentiation of induced pluripotent stem cells for future olfactory repair using an indirect co-culture technique.International journal of clinical and experimental pathology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The capacity of the peripheral olfactory system to recover after injury has not been thoroughly explored. P2-IRES-tauLacZ mice were exposed to methyl bromide, which causes epithelial damage and kills 90% of the P2 neurons. With subsequent neuronal regeneration, P2 neurons recover within their usual territory to equal control numbers by 1 month but then decline sharply to roughly 40% of control by 3 months. At this time, the P2 projection onto the olfactory bulb is erroneous in several respects. Instead of converging onto 1 or 2 glomeruli per surface, small collections of P2 axons innervate multiple glomeruli at roughly the same position in the bulb as in controls. Within these glomeruli, the P2 axons are aggregated near the edge, whereas the remainder of the glomerulus contains olfactory marker protein (+), non-P2 axons, violating the one receptor-one glomerulus rule normally observed. The aggregates are denser than found in control P2-innervated glomeruli, suggesting that the P2 axons may not be synaptically connected. Based on published literature and other data, we hypothesize that P2 neurons lose out in an activity-based competition for synaptic territory within the glomeruli and are not maintained at control numbers due to a lack of trophic support from the bulb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.