ArticleMarine drugs2014
Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- Asymmetric Total Synthesis of (+)-Ineleganolide.Angewandte Chemie (International ed. in English) · 2026Article
- Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Synthetic strategy toward ineleganolide: A cautionary tale.Tetrahedron · 2021Article
- Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral GenusMarine drugs · 2021Review
- Anti-Inflammatory Cembranoids from a Formosa Soft CoralMarine drugs · 2020Article
- Bridging the gap between natural product synthesis and drug discovery.Natural product reports · 2020Review
- Ten-Year Research Update Review: Antiviral Activities from Marine Organisms.Biomolecules · 2020Review
- An Unexpected Transannular [4+2] Cycloaddition during the Total Synthesis of (+)-Norcembrene 5.Angewandte Chemie (International ed. in English) · 2020Article
- Oceans as a Source of Immunotherapy.Marine drugs · 2019Review
- Marine Microalgae: Promising Source for New Bioactive Compounds.Marine drugs · 2018Article
- New Cembranoids and a Biscembranoid Peroxide from the Soft CoralMarine drugs · 2018Article
- Marine-derived protein kinase inhibitors for neuroinflammatory diseases.Biomedical engineering online · 2018Review
- Development of a Unified Enantioselective, Convergent Synthetic Approach Toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Asymmetric Formation of the Polycyclic Norditerpenoid Carbocyclic Core by Tandem Annulation Cascade.The Journal of organic chemistry · 2018Article
- Model Studies To Access the [6,7,5,5]-Core of Ineleganolide Using Tandem Translactonization-Cope or Cyclopropanation-Cope Rearrangements as Key Steps.The Journal of organic chemistry · 2017Article
- Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.Marine drugs · 2017Article
- Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank.Marine drugs · 2017Article
- Polycyclic Furanobutenolide-Derived Cembranoid and Norcembranoid Natural Products: Biosynthetic Connections and Synthetic Efforts.Chemical reviews · 2017Review
- Enantioselective, Convergent Synthesis of the Ineleganolide Core by a Tandem Annulation Cascade.Chemical science · 2017Article
- Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine organisms and their metabolites represent a unique source of potential pharmaceutical substances. In this study, we examined marine-derived substances for their bioactive properties in a cell-based Chikungunya virus (CHIKV) replicon model and for in vitro anti-inflammatory activity. In the screening of a marine sample library, crude extracts from the Indian soft coral, Sinularia kavarattiensis, showed promising activity against the CHIKV replicon. Bioassay-guided chemical fractionation of S. kavarattiensis resulted in the isolation of six known norcembranoids (1-6) and one new compound, named kavaranolide (7). The structures were elucidated on the basis of NMR and MS spectroscopic data. Compounds 1-3 and 5-7 were evaluated for their replicon-inhibiting potential in the CHIKV model by using a luminescence-based detection technique and live cell imaging. Compounds 1 and 2 showed moderate inhibition of the CHIKV replicon, but imaging studies also revealed cytotoxic properties. Moreover, the effects of the isolated compounds on primary microglial cells, an experimental model for neuroinflammation, were evaluated. Compound 2 was shown to modulate the immune response in microglial cells and to possess potential anti-inflammatory properties by dose-dependently reducing the release of pro- and anti-inflammatory cytokines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.