ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Striatal morphology is associated with tobacco cigarette craving.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations.Behavioral and brain functions : BBF · 2016Pooled it
- Age of onset of nicotine use and severity of nicotine addiction symptoms are associated with hippocampal volume in late adolescents and emerging adults.Frontiers in adolescent medicine · 2025Article
- Effects of Smoking Status and State on Intrinsic Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Comparison of frontostriatal circuits in adolescent nicotine addiction and internet gaming disorder.Journal of behavioral addictions · 2022Review
- Characterizing the Subcortical Structures in Youth with Congenital Heart Disease.AJNR. American journal of neuroradiology · 2020Article
- Interactive effects of age and recent substance use on striatal shape morphology at substance use disorder treatment entry.Drug and alcohol dependence · 2020Article
- Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- The Impact of Combinations of Alcohol, Nicotine, and Cannabis on Dynamic Brain Connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits.Scientific reports · 2017Article
- The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging.Translational psychiatry · 2017Article
- Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder.Addiction biology · 2017Article
- Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study.Scientific reports · 2017Article
- Brain anatomy alterations associated with Social Networking Site (SNS) addiction.Scientific reports · 2017Article
- Subcortical Shape Changes, Hippocampal Atrophy and Cortical Thinning in Future Alzheimer's Disease Patients.Frontiers in aging neuroscience · 2017Article
- An electrophysiological dissociation of craving and stimulus-dependent attentional capture in smokers.Cognitive, affective & behavioral neuroscience · 2016Article
- The implication of frontostriatal circuits in young smokers: A resting-state study.Human brain mapping · 2016Article
- Multi-atlas segmentation of biomedical images: A survey.Medical image analysis · 2015Review
- Insula-Dorsal Anterior Cingulate Cortex Coupling is Associated with Enhanced Brain Reactivity to Smoking Cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Striatal shape abnormalities as novel neurodevelopmental endophenotypes in schizophrenia: a longitudinal study.Human brain mapping · 2015Article
- Personality disorder symptomatology is associated with anomalies in striatal and prefrontal morphology.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The striatum has a clear role in addictive disorders and is involved in drug-related craving. Recently, enhanced striatal volume was associated with greater lifetime nicotine exposure, suggesting a bridge between striatal function and structural phenotypes. To assess this link between striatal structure and function, we evaluated the relationship between striatal morphology and this brain region's well-established role in craving. In tobacco smokers, we assessed striatal volume, surface area, and shape using a new segmentation methodology coupled with local shape indices. Striatal morphology was then related with two measures of craving: state-based craving, assessed by the brief questionnaire of smoking urges (QSU), and craving induced by smoking-related images. A positive association was found between left striatal volume and surface area with both measures of craving. A more specific relationship was found between both craving measures and the dorsal, but not in ventral striatum. Evaluating dorsal striatal subregions showed a single relationship between the caudate and QSU. Although cue-induced craving and the QSU were both associated with enlarged striatal volume and surface area, these measures were differentially associated with global or more local striatal volumes. We also report a connection between greater right striatal shape deformations and cue-induced craving. Shape deformations associated with cue-induced craving were specific to striatal subregions involved in habitual responding to rewarding stimuli, which is relevant given the habitual nature of cue-induced craving. The current findings confirm a relationship between striatal function and morphology and suggest that variation in striatal morphology may be a biomarker for craving severity.
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