ArticleCerebral cortex (New York, N.Y. : 1991)2015
Abnormal Neural Activation to Faces in the Parents of Children with Autism.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Neuroanatomical and neurofunctional markers of social cognition in autism spectrum disorder.Human brain mapping · 2016Pooled it
- Trial
- Subclinical neuropsychiatric trait variation in parents of children with autism spectrum disorder: a cohort study.Molecular autism · 2026Article
- Narrative Ability in Autism and First-Degree Relatives.Journal of autism and developmental disorders · 2025Article
- Endophenotype trait domains for advancing gene discovery in autism spectrum disorder.Journal of neurodevelopmental disorders · 2023Review
- Neural Processing of Speech Sounds in ASD and First-Degree Relatives.Journal of autism and developmental disorders · 2023Article
- A constellation of eye-tracking measures reveals social attention differences in ASD and the broad autism phenotype.Molecular autism · 2022Article
- Contributions of face processing, social anhedonia and mentalizing to the expression of social autistic-like traits.Frontiers in behavioral neuroscience · 2022Article
- Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults.Journal of autism and developmental disorders · 2021Article
- A Unique Visual Attention Profile Associated With theFrontiers in genetics · 2021Article
- Brain connectivity analysis in fathers of children with autism.Cognitive neurodynamics · 2020Article
- Brain function distinguishes female carriers and non-carriers of familial risk for autism.Molecular autism · 2020Article
- Understanding Social Communication Differences in Autism Spectrum Disorder and First-Degree Relatives: A Study of Looking and Speaking.Journal of autism and developmental disorders · 2020Article
- Brain Network Organization Correlates with Autistic Features in Preschoolers with Autism Spectrum Disorders and in Their Fathers: Preliminary Data from a DWI Analysis.Journal of clinical medicine · 2019Article
- Broader autism phenotype in parents of children with autism: a systematic review of percentage estimates.Journal of child and family studies · 2018Article
- Second Version of Google Glass as a Wearable Socio-Affective Aid: Positive School Desirability, High Usability, and Theoretical Framework in a Sample of Children with Autism.JMIR human factors · 2018Article
- The Diagnosis of Autism Spectrum Disorder Based on the Random Neural Network Cluster.Frontiers in human neuroscience · 2018Article
- Neurobiological Aspects of Face Recognition: The Role of Oxytocin.Frontiers in behavioral neuroscience · 2018Review
- Links between looking and speaking in autism and first-degree relatives: insights into the expression of genetic liability to autism.Molecular autism · 2018Article
- Neural correlates of naturalistic social cognition: brain-behavior relationships in healthy adults.Social cognitive and affective neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Parents of children with an autism spectrum disorder (ASD) show subtle deficits in aspects of social behavior and face processing, which resemble those seen in ASD, referred to as the "Broad Autism Phenotype " (BAP). While abnormal activation in ASD has been reported in several brain structures linked to social cognition, little is known regarding patterns in the BAP. We compared autism parents with control parents with no family history of ASD using 2 well-validated face-processing tasks. Results indicated increased activation in the autism parents to faces in the amygdala (AMY) and the fusiform gyrus (FG), 2 core face-processing regions. Exploratory analyses revealed hyper-activation of lateral occipital cortex (LOC) bilaterally in autism parents with aloof personality ("BAP+"). Findings suggest that abnormalities of the AMY and FG are related to underlying genetic liability for ASD, whereas abnormalities in the LOC and right FG are more specific to behavioral features of the BAP. Results extend our knowledge of neural circuitry underlying abnormal face processing beyond those previously reported in ASD to individuals with shared genetic liability for autism and a subset of genetically related individuals with the BAP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.