ArticleGenome biology and evolution2014
Evolution of functional diversification within quasispecies.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Spatial structure: shaping the ecology and evolution of microbial communities.FEMS microbiology reviews · 2026Review
- Obligate endosymbiosis enables genome expansion during eukaryogenesis.Communications biology · 2023Article
- Evolution of genome fragility enables microbial division of labor.Molecular systems biology · 2023Article
- Modelling the evolution of novelty: a review.Essays in biochemistry · 2022Article
- Nothing in evolution makes sense except in the light of parasitism: evolution of complex replication strategies.Royal Society open science · 2021Article
- Characterization of EIAVViruses · 2019Article
- On the networked architecture of genotype spaces and its critical effects on molecular evolution.Open biology · 2018Review
- Conceptualizing the origin of life in terms of evolution.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Review
- Evolutionary Conflict Leads to Innovation: Symmetry Breaking in a Spatial Model of RNA-Like Replicators.Life (Basel, Switzerland) · 2017Article
- Tag mechanism as a strategy for the RNA replicase to resist parasites in the RNA world.PloS one · 2017Article
- Parasites Sustain and Enhance RNA-Like Replicators through Spatial Self-Organisation.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to quasispecies theory, high mutation rates limit the amount of information genomes can store (Eigen's Paradox), whereas genomes with higher degrees of neutrality may be selected even at the expenses of higher replication rates (the "survival of the flattest" effect). Introducing a complex genotype to phenotype map, such as RNA folding, epitomizes such effect because of the existence of neutral networks and their exploitation by evolution, affecting both population structure and genome composition. We reexamine these classical results in the light of an RNA-based system that can evolve its own ecology. Contrary to expectations, we find that quasispecies evolving at high mutation rates are steep and characterized by one master sequence. Importantly, the analysis of the system and the characterization of the evolved quasispecies reveal the emergence of functionalities as phenotypes of nonreplicating genotypes, whose presence is crucial for the overall viability and stability of the system. In other words, the master sequence codes for the information of the entire ecosystem, whereas the decoding happens, stochastically, through mutations. We show that this solution quickly outcompetes strategies based on genomes with a high degree of neutrality. In conclusion, individually coded but ecosystem-based diversity evolves and persists indefinitely close to the Information Threshold.
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