ArticleAmerican journal of physiology. Renal physiology2014
Somatic modulation of spinal reflex bladder activity mediated by nociceptive bladder afferent nerve fibers in cats.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Influence of transcutaneous tibial nerve stimulation on postoperative catheter-related bladder discomfort in urology: a prospective randomized controlled trial.Scientific reports · 2025Trial
- Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats.European journal of medical research · 2025Article
- Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model.Scientific reports · 2024Article
- Peroneal Electric Transcutaneous NeuroModulation (eTNMJournal of healthcare engineering · 2021Article
- Response of hypogastric afferent fibers to bladder distention or irritation in cats.Experimental neurology · 2020Article
- Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation.Frontiers in systems neuroscience · 2020Article
- Behavioral Monitoring and Neuromodulation of Feline Voiding Function.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2019Article
- Effects of Genital Nerve Stimulation Amplitude on Bladder Capacity in Spinal Cord Injured Subjects.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Spinal interneuronal mechanisms underlying pudendal and tibial neuromodulation of bladder function in cats.Experimental neurology · 2018Article
- Lumbosacral spinal cord epidural stimulation improves voiding function after human spinal cord injury.Scientific reports · 2018Article
- Lumbosacral spinal segmental contributions to tibial and pudendal neuromodulation of bladder overactivity in cats.Neurourology and urodynamics · 2017Article
- Sacral neuromodulation of nociceptive bladder overactivity in cats.Neurourology and urodynamics · 2017Article
- Role of cannabinoid receptor type 1 in tibial and pudendal neuromodulation of bladder overactivity in cats.American journal of physiology. Renal physiology · 2017Article
- Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives.Medical devices (Auckland, N.Z.) · 2017Review
- Influence of urothelial or suburothelial cholinergic receptors on bladder reflexes in chronic spinal cord injured cats.Experimental neurology · 2016Article
- Stimulus frequency-dependent inhibition of micturition contractions of the urinary bladder by electrical stimulation of afferent Aβ, Aδ, and C fibers in cutaneous branches of the pudendal nerve.The journal of physiological sciences : JPS · 2016Article
- Does central sensitization help explain idiopathic overactive bladder?Nature reviews. Urology · 2016Review
- Modeling the spinal pudendo-vesical reflex for bladder control by pudendal afferent stimulation.Journal of computational neuroscience · 2016Article
- Pudendal but not tibial nerve stimulation inhibits bladder contractions induced by stimulation of pontine micturition center in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Role of the brain stem in tibial inhibition of the micturition reflex in cats.American journal of physiology. Renal physiology · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The goal of the present study was to determine if supraspinal pathways are necessary for inhibition of bladder reflex activity induced by activation of somatic afferents in the pudendal or tibial nerve. Cats anesthetized with α-chloralose were studied after acute spinal cord transection at the thoracic T9/T10 level. Dilute (0.25%) acetic acid was used to irritate the bladder, activate nociceptive afferent C-fibers, and trigger spinal reflex bladder contractions (amplitude: 19.3 ± 2.9 cmH2O). Hexamethonium (a ganglionic blocker, intravenously) significantly (P < 0.01) reduced the amplitude of the reflex bladder contractions to 8.5 ± 1.9 cmH2O. Injection of lidocaine (2%, 1-2 ml) into the sacral spinal cord or transection of the sacral spinal roots and spinal cord further reduced the contraction amplitude to 4.2 ± 1.3 cmH2O. Pudendal nerve stimulation (PNS) at frequencies of 0.5-5 Hz and 40 Hz but not at 10-20 Hz inhibited reflex bladder contractions, whereas tibial nerve stimulation (TNS) failed to inhibit bladder contractions at all tested frequencies (0.5-40 Hz). These results indicate that PNS inhibition of nociceptive afferent C-fiber-mediated spinal reflex bladder contractions can occur at the spinal level in the absence of supraspinal pathways, but TNS inhibition requires supraspinal pathways. In addition, this study shows, for the first time, that after acute spinal cord transection reflex bladder contractions can be triggered by activating nociceptive bladder afferent C-fibers using acetic acid irritation. Understanding the sites of action for PNS or TNS inhibition is important for the clinical application of pudendal or tibial neuromodulation to treat bladder dysfunctions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.