ArticleAmerican journal of physiology. Renal physiology2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
Article in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4).Journal of immunology research · 2023Article
- Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy.Journal of diabetes research · 2023Review
- Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.Cell death & disease · 2022Article
- The functions and roles of sestrins in regulating human diseases.Cellular & molecular biology letters · 2022Review
- Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function.Oxidative medicine and cellular longevity · 2021Review
- Effect of Aerobic Exercise on Oxidative Stress and Inflammatory Response During Particulate Matter Exposure in Mouse Lungs.Frontiers in physiology · 2021Article
- Transplantation of mesenchymal stem cells preserves podocyte homeostasis through modulation of parietal epithelial cell activation in adriamycin-induced mouse kidney injury model.Histology and histopathology · 2020Article
- CD44 impacts glomerular parietal epithelial cell changes in the aged mouse kidney.Physiological reports · 2020Article
- Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis.Scientific reports · 2020Article
- Induction of sestrin 2 is associated with fisetin-mediated apoptosis in human head and neck cancer cell lines.Journal of clinical biochemistry and nutrition · 2019Article
- Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease.Stem cell research & therapy · 2018Article
- The role of sirolimus in proteinuria in diabetic nephropathy rats.Iranian journal of basic medical sciences · 2017Article
- Parietal cells-new perspectives in glomerular disease.Cell and tissue research · 2017Article
- Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases.Oxidative medicine and cellular longevity · 2017Review
- Reducing mTOR augments parietal epithelial cell density in a model of acute podocyte depletion and in aged kidneys.American journal of physiology. Renal physiology · 2016Article
- Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.Nature communications · 2015Article
- Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response.PloS one · 2015Article
- Sestrin 2: a regulator of the glomerular parietal epithelial cell phenotype.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sestrin 2, initially identified as a p53 target protein, accumulates in cells exposed to stress and inhibits mammalian target of rapamycin (mTOR) signaling. In normal rat kidneys, sestrin 2 was selectively expressed in parietal epithelial cells (PECs), identified by the marker protein gene product 9.5. In adriamycin nephropathy, sestrin 2 expression decreased in PECs on day 14, together with increased expression of phosphorylated S6 ribosomal protein (P-S6RP), a downstream target of mTOR. Sestrin 2 expression was markedly decreased on day 42, coinciding with glomerulosclerosis and severe periglomerular fibrosis. In puromycin aminonucleoside nephropathy, decreased sestrin 2 expression, increased P-S6RP expression, and periglomerular fibrosis were observed on day 9, when massive proteinuria developed. These changes were transient and nearly normalized by day 28. In crescentic glomerulonephritis, sestrin 2 expression was not detected in cellular crescents, whereas P-S6RP increased. In conditionally immortalized cultured PECs, the forced downregulation of sestrin 2 by short hairpin RNA resulted in increased expression of P-S6RP and increased apoptosis. These data suggest that sestrin 2 is involved in PEC homeostasis by regulating the activity of mTOR. In addition, sestrin 2 could be a novel marker of PECs, and decreased expression of sestrin 2 might be a marker of PEC injury.
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