Evidence map›Paper›PMID 25056047›Full record

ArticleNature2014

Medical research: treat ageing.

Luigi Fontana, Brian K Kennedy, Valter D Longo, Douglas Seals, Simon Melov

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Leveraging mitochondrial stress to improve healthy aging.Sports medicine and health science · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Testing scenarios for using telepresence robots in healthcare settings.Computational and structural biotechnology journal · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Luigi FontanaWashington University in St. Louis, Missouri, USA, and at Brescia University, Italy.
Brian K KennedyBuck Institute for Research on Aging in Novato, California, USA.
Valter D LongoLongevity Institute at the University of Southern California in Los Angeles, USA.
Douglas SealsDepartment of Integrative Physiology at the University of Colorado Boulder in Boulder, Colorado, USA.
Simon MelovBuck Institute for Research on Aging in Novato, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Age of OnsetAgingAnimalsBiomarkersBiomedical ResearchCaloric RestrictionClinical Trials as TopicDietExerciseGeriatricsHealthHumansLongevityMetforminModels, AnimalPrecision MedicineBiomarkersMetforminSirolimus

Identifiers

PMID25056047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.